rs7216389多态性与我国汉族人群哮喘易感性的相关性研究

Association analysis of rs7216389 and asthma susceptibility

目的探讨rs7216389多态性与哮喘发病风险的相关性,为哮喘的有效预警提供新的候选分子标志物。方法采用病例对照研究,检测72例哮喘患者(病例组)及87例健康个体(对照组)中rs7216389多态位点基因型,进行关联分析。结果样本均衡性检验显示病例组与对照组个体之间在性别(P=0.762)、年龄(P=0.807)分布无统计学差异;哈德温伯格平衡检测显示对照组个体符合遗传学规律(P=0.418);rs7216389位点CC、CT、TT基因型在病例组中的分布频率分别为4.2%、34.7%和61.1%,在对照组中为12.6%、40.2%和47.1%,T为风险等位基因(TT vs.CC,OR=3.93,95%CI 1.02-15.11,P=0.034;T vs.C,OR=1.78,95%CI 1.07-2.95,P=0.026)。结论 rs7216389多态性与我国汉族人群哮喘易感性显著相关,有望作为哮喘早期预警筛查的候选分子标志物。

Objective To explore the association of asthma susceptibility with rs7216389 polymorphism and to provide reference for early warning of asthma. Methods 72 asthma patients and 87 healthy individuals were enrolled. χ~2 test,t test and HWE test were conducted to examine the study populations,then the association between rs7216389 polymorphism and asthma susceptibility was analyzed. Results The T allele was associated with increased asthma risk( TT vs. CC,OR = 3. 93,95% CI 1. 02-15. 11,P = 0. 034; T vs. C,OR = 1. 78,95% CI1. 07-2. 95,P = 0. 026). Conclusion rs7216389 polymorphism is associated with asthma susceptibility of Chinese Han population,which may be helpful for the early warning of asthma.