血清胆固醇及肝功能指标对胆结石诊断的意义研究

Study on the correlation between Serum cholesterol and liver function index and gallstone

目的探讨血清中胆固醇含量及肝功能指标与胆结石发病的相关性及对病情的预示意义。方法采用生化检测仪对128例胆结石患者和86例健康人进行血清胆固醇(TC)及肝功能指标的检测;通过ROC曲线分析各指标鉴别胆结石患者和健康对照者的特异性和灵敏度,并利用尤登指数计算诊断分界值。结果胆结石患者的TC及谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、总胆红素(TB)和间接胆红素(IB)的含量均高于对照组,且差异具有统计学意义(P<0.05)。TC、ALT、AST、ALP、TB和IB在胆结石患者和健康对照者之间的诊断临界值分别为:TC>4.36 mmol/L、ALT>40.20 U/L、AST>38.53 U/L、ALP>142.66 U/L、TB>10.68μmol/L、IB>6.39μmol/L。结论 TC和ALT、AST、ALP、TB、IB与胆结石有相关性,可以作为早期胆结石诊断的辅助参考指标。

Objective To explore the correlation between serum cholesterol and liver function index and gallstone. Methods The levels of serum cholesterol and liver function index of 128 cases gallstone patients and 50 cases of healthy individuals were examined using automatic biochemical analyzer. ROC curve was applied to analyze the various indicators for the diagnosis of gallstone of specificity and sensitivity and determine diagnostic threshold value by Youden index. Results The concentration of serum cholesterol（ TC） and liver function index ： glutamic-pyruvic transaminase（ ALT）,glutamic oxalacetic transaminase（ AST）,alkaline phosphatase（ ALP）,total bilirubin（ TB） and indirect bilirubin（ IB） of the gallstone patients were higher than that of the healthy individuals. The difference had statistical significance between the two groups（ P 〈0. 05）; The threshold value of TC,ALT,AST,ALP,TB,IB was 4. 36,40. 20,8. 53,142. 66,10. 68,6. 39,respectively.Conclusion The serum cholesterol（ TC） and liver function index（ ALT,AST,ALP,TB,IB） were the risk factors of gallstone,which could be a reference for the early diagnosis of gallstones.