cTnI及NT-proBNP水平与慢性阻塞性肺疾病急性发作期患者是否合并肺动脉高压的相关性研究

Correlation study on serum levels of NT-proBNP and cTnI in acute exacerbation of patients with chronic obstructive pulmonary disease combined or not combined with pulmonary hypertension

目的探讨肌钙蛋白I(cTnI)及氨基末端脑钠肽前体(NT-proBNP)水平与慢性阻塞性肺疾病急性发作期患者的肺动脉压力之间的关系。方法选取急诊科76例慢性阻塞性肺疾病急性加重期患者进行cTnI、NT-proBNP检测,并通过心脏超声测得肺动脉收缩压值(PASP)将其分为两组,其中肺动脉高压组(>30mmHg)42例和肺动脉压正常组(≤30mmHg)34例。观察cTnI、NT-ProBNP水平在慢性阻塞性肺疾病急性发作期患者与肺动脉压力的相关性。结果慢性阻塞性肺疾病急性发作期合并肺动脉高压组的cTnI水平和NT-proBNP水平分别为(0.054±0.031ng/ml)和(663.24±185.26pg/ml),肺动脉压正常组的cTnI水平和NT-proBNP水平分别为(0.038±0.019ng/ml)和(495.68±171.97pg/ml),差异具有统计学意义(P<0.05)。结论慢性阻塞性肺疾病急性发作期患者合并肺动脉压力增高时cTnI和NT-proBNP的水平明显增高,所以cTnI和NT-proBNP可作为慢性阻塞性肺疾病急性发作期患者是否合并肺动脉高压的可靠指标。

Objective To explore the relationship between serum levels of cardiac troponin I （cTnl） , N - terminal probrain natrium peptide （NT-proBNP） and pulmonary arterial pressure in patients with acute exacerbation of chronic obstructive pulmonary disease （ AECOPD）. Methods Pulmonary artery systolic pressure （ PASP） was measured in 76 patients with AECOPD by echocardiography, then they were divided in-to two groups according to PASP pulmonary hypertension group （ 〉30 mmHg） 42 cases and normal group （ ^ 3 0 mmHg） 34 cases. In order to measure the serum levels of cTnl and NT - Pro BNP in patients with AECOPD and its correlation with pulmonary hypertension. Results The ser-um levels of cTnl and NT - proBNP in patients with AECOPD combining pulmonary hypertension group were 0？ 054 ±0. 031 ng/ml and 663. 24 土 185.26 pg/ml respectively,and those in normal ones were 0.038 ± 0.019 ng/ml and 495. 68 ± 171 .97 pg/ml respectively. The difference was statistically significant （ P 〈0.05） . Conclusion The levels of two indicators are significantly elevated in AECOPD patients complicated with pulmonary hypertension than those of normal ones. They can be used as reliable indicators for the assessment of AECOPD patients complicated or not complicated with pulmonary hypertension.