阿司匹林与比索洛尔联合用药对冠心病经皮冠状动脉介入术后患者心脏康复的影响

Effect of aspirin and bissrol on the cardiac rehabilitation of patients with coronary artery disease after coronary artery intervention

目的探究阿司匹林与比索洛尔联合用药对冠心病经皮冠状动脉介入术(PCI)后患者心脏康复的影响。方法采用回顾性分析的方法将2014年9月至2016年9月接受经皮冠状动脉介入术治疗的60例冠心病患者作为研究对象,并给予随机分组。对照组30例,给予单纯阿司匹林治疗;干预组30例,给予阿司匹林与比索洛尔联合治疗。对两组患者治疗前后6 min步行实验结果、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左心室壁厚度(LVPWT)、左室射血分数(LVEF)和舒张功能等心功能相关指标以及不良反应发生情况进行综合评价。结果干预组患者治疗后的6 min步行距离、心率等指标显著优于对照组,差异有统计学意义(P<0.05);干预组治疗后的LVEDD、LVESD、LVEF和舒张功能正常率等心功能相关指标明显优于对照组,差异有统计学意义(P<0.05);且干预组治疗后仅有1例患者出现不良反应,占3.3%,低于对照组不良反应发生率(10.0%),但差异无统计学意义(P>0.05)。结论阿司匹林联合比索洛尔治疗冠心病经皮冠状动脉介入术后患者,对患者的心功能具有显著改善作用,不增加不良反应,值得临床推广应用。

Objective To explore the effect of aspirin and bissrol on the cardiac rehabilitation of patients with coronary artery disease（ PCI） after coronary artery disease（ PCI）. Methods From September 2014 to September 2016 in our hospital 60 patients with coronary heart disease（ CHD） after percutaneous coronary interention treatment were selected as the research object,and were randomly divided into two groups：Control group 30 cases with simple aspirin treatment; Intervention group 30 cases with aspirin and pesos bisoprolol combination treatment. 6 min walking experiments,left ventricular end-diastolic diameter（ LVEDD）,left ventricular end systolic diameter（ LVESD）,left ventricular wall thickness（ LVPWT）,left ventricular ejection fraction（ LVEF） and other related parameters of cardiac function and adverse reaction were comprehensively evaluated. Results The 6 min walking distance and heart rate of the intervention group were significantly better than those in the control group（ P 〈 0. 05）,which was statistically significant. The LVEDD,LVESD,LVEF and other related indicators of the intervention group were significantly different with those in the control group（ P 〈 0. 05）,which was statistically significant. After the interventional therapy,the adverse events（ 3. 3%） in the intervention group was lower than that in the control group（ 10. 0%）,but the difference was not statistically significant（ P〉 0. 05）. Conclusion Aspirin combined with bisoprolol in patients with coronary heart disease after percutaneous coronary intervention has significant effect on cardiac function in patients with and without increasing adverse reactions. It is worthy of clinical popularization and application.