摘要
glmS核酶是存在于革兰氏阳性细菌中,对葡糖胺-6-磷酸(GlcN6P)的合成起反馈抑制作用的核糖开关。同时,glmS核糖开关是一种位于glmS基因5′非翻译区的自剪切核酶。glmS核糖开关/核酶通过结合GlcN6P后自剪切抑制下游基因glmS的表达。对glmS核糖开关结构和功能的研究将有助于开发新的抗生素作用靶点。本文对glmS核糖开关的结构和功能进行阐述并介绍glmS核糖开关近年来的研究进展和应用。
The glmS ribozyme is predominantly present in gram-positive bacteria, and it is a riboswitch that inhibits the synthesis of glucosamine-6-phosphate. In addition, glmS riboswitch is a self-cleft ribozyme located in the 5＇ untranslated region of the glmS gene. Study on the structure and function of glmS riboswitch will be beneficial to develop new targets for antibiotic action. In this paper, we reviewed the structure and function of glmS riboswitch. In addition, we also introduce recent research progress and application of glmS riboswitch.
作者
周丁
王倩
祁庆生
Ding Zhou Qian Wang Qingsheng Qi(National Glycoengineering Research Center, Shandong University, Jinan 250100, Shandong Province, China State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, Shandong Province, China)
出处
《微生物学报》
CAS
CSCD
北大核心
2017年第8期1152-1159,共8页
Acta Microbiologica Sinica
基金
国家自然科学基金(31670077)~~
