腹腔镜下胆囊切除术患者应用帕瑞昔布钠对血清前列腺素E_2的影响及术后镇痛效果分析

Effect of postoperative analgesia and influence on PGE_2 of Parecoxib Sodium in patients with laparoscopic cholecystectomy

目的探讨腹腔镜下胆囊切除术患者应用帕瑞昔布钠对血清前列腺素E_2(PGE_2)的影响及术后镇痛效果。方法选取我院2015年6月~2017年4月收治的150例腹部腔镜手术患者,按随机数字表法和双盲法分为A(生理盐水空白对照组)、B(帕瑞昔布组)、C(帕瑞昔布和舒芬太尼术后镇痛组)三组,每组50例。对三组患者术后不同时间点的PGE_2浓度以及疼痛程度进行对比分析。结果 B组患者术后1、6、12、24 h的PGE_2浓度均比其他两组更低,差异有统计学意义(P<0.05);B组患者术后1、6、12、24 h的VAS评分值也是三组最低,差异有统计学意义(P<0.01)。结论腹腔镜下胆囊切除术患者应用帕瑞昔布钠能缓解血清PGE_2升高,降低PGE_2的浓度,术后镇痛效果明显,值得推广实施。

Objective To investigate the effect of laparoscopic cholecystectomy in patients with application of Parecoxib Sodium on serum prostaglandin E2 （PGE2） and the effect of postoperative analgesia.Methods A total of 150 cases of ab- dominal laparoscopic surgery patients in our hospital from June 2015 to April 2017 were selected and divided into group A （saline blank control group）,B （Parecoxib group） and C （Postoperative analgesic group of Parecoxib and Sufen- tanil） according to the random number table method and double blind method,50 cases in each group.The PGE2 con- centration and the degree of pain at different time points after surgery of three groups were compared.Results The PGE2 concentration of patients in group B 1,6,12 and 24 h after operation were lower than those of the other two groups,and the difference was statistically significant （P〈0.05）.The VAS score of patients in group B 1,6,12 and 24 h after operation were the lowest one in the three groups,and the difference was statistically significant （P〈0.01）.Conclusion Laparoscopic choleeystectomy in patients with application of Parecoxib Sodium can increase the alleviate serum PGE2 and decrease the concentration of PGE2.The postoperative analgesic effect is obvious and worth promoting.