高血脂患者血液流变学指标及其对肝功能生化检测的影响

Hemorheological indexes of patients with hyperlipidemia and their influence on biochemical detection of liver functions

目的探讨高血脂患者血液流变指标及其对肝功能生化检测的影响。方法选取2016年1月~2017年1月于我院确诊高血脂并接受治疗的60例患者作为观察组,选取同期于我院进行体检的60例健康人作为对照组。比较两组的血液流变相关指标(全血黏度低切10/s、全血黏度中切60/s、全血黏度高切150/s、血浆黏度120/s)和肝功能生化相关指标[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(γ-GT)]。结果观察组的全血低切10/s、全血中切60/s、全血高切150/s、血浆黏度120/s水平显著高于对照组,差异有统计学意义(P<0.05)。观察组的ALT、AST、γ-GT水平显著高于对照组,差异有统计学意义(P<0.05)。结论临床上对高血脂患者血液流变指标及肝功能生化检测指标进行检测,其值均明显高于正常人群,这有利于早期诊断预防和治疗,具有应用和推广价值。

Objective To investigate hemorheological indexes of patients with hyperlipidemia and their influence on biochemical detection of liver functions.Methods Altogether 60 patients who were diagnosed as hyperlipemia and treated from January 2016 to January 2017 in our hospital were selected as the observation group,60 healthy people who underwent physical examinations in our hospital over the same period were selected as the control group.The hemorheo- logical indexes （whole blood viscosity at low Shear rate 10/s,whole blood viscosity at middle shear rate 60/s,whole blood viscosity at high shear rate 150/s,plasma viscosity 120/s） and the liver function index [alanine aminotransferase （ALT）, aspartate aminotransferase （AST）,γ-glutamyl transpeptidase （γ-GT）] of the two groups were compared.Results The level of whole blood viscosity at low shear rate 10/s,whole blood viscosity at middle shear rate 60/s,whole blood viscosity at high shear rate 150/s,plasma viscosity 120/s in the observation group was higher than that in the control group,with significant difference （P〈0.05）.The levels of ALT,AST and γ-GT in the observation group was significantly higher than that in the control group,with significant difference （P〈0.05）.Conclusion The hemorheological indexes and biochemical indicators of liver function of patients with hyperlipidemia are clinically tested and proven to be significantly higher than the normal population,which is conducive to the early diagnosis,prevention and trea（ment and has the use and promotion value.