双歧三联活菌肠溶胶囊联合早期肠内营养对急性脑梗死患者营养状态及胃肠功能的影响

Influence of Bifid Triple Viable Capsules combined with early enteral nutrition on nutritional status and gastrointestinal function for patients with acute cerebral infarction

目的探讨双歧三联活菌肠溶胶囊联合早期肠内营养对急性脑梗死患者营养状态及胃肠功能的影响。方法选择我院2015年9月~2016年7月收治的急性脑梗死患者74例为研究对象,以随机数字表法将其分为观察组与对照组,各37例。对照组采用早期肠内营养,观察组采用双歧三联活菌肠溶胶囊联合早期肠内营养。观察两组患者的营养状态及胃肠功能情况。结果干预前,两组患者的前白蛋白(PA)、血红蛋白(Hb)、白蛋白(Alb)、转铁蛋白(TRF)营养指标差异无统计学意义(P>0.05),干预后,观察组的各项营养指标均优于对照组,差异有统计学意义(P<0.05);干预前,两组患者的D-乳酸、内毒素、血清二胺氧化酶(DAO)、尿乳果糖/甘露醇(L/M)值等肠道黏膜功能指标差异无统计学意义(P>0.05),干预后,两组患者的肠道黏膜功能各项指标均有所改善,且观察组的各指标均明显低于对照组,差异有统计学意义(P<0.05);观察组的腹泻、腹胀、呕吐、便秘发生率均低于对照组,差异有统计学意义(P<0.05)。结论双歧三联活菌肠溶胶囊联合早期肠内营养可改善急性脑梗死患者的营养状态,也能改善其胃肠功能,起到辅助治疗作用,值得临床推广。

Objective To discuss the influence of Bifid Triple Viable Capsules combined with early enteral nutrition on nutritional status and gastrointestinal function for patients with acute cerebral infarction.Methods 74 patients with acute cerebral infarction treated in our hospital from September 2015 to July 2016 were selected as the research objects,and they were divided into the observation group and the control group according to the random number method, and there were 37 cases in each group.The control group was given early enteral nutrition,while the observation group was given Bifid Triple Viable Capsules combined with early enteral nutrition.Then,the nutritional status and gastrointestinal function of patients in two groups were observed.Results Before intervention,there was no significant difference in prealbumin （PA）,hemoglobin （Hb）,albumin （Alb）,transferrin （TRF） between the two groups （P〉0.O5）.After intervention,the nutritional indexes in the observation group were better than those in the control group,and the difference was statistically significant （P〈0.05）;Before intervention,there was no significant difference in the function of intestinal mucosa such as D- lactic acid,endotoxin,serum two amine oxidase （DAO）,urinary lactulose / mannitol （L/M） value between the two group （P〉0.05）.After intervention,the intestinal mucosal function indicators of patients in two groups had been improved,but the each index in the observation group was significantly lower than those in the control group,and the difference was statistically significant （P〈0.05）.The incidence of diarrhea,abdominal distension,vomiting and constipation in the observation group was lower than that in the control group,and the difference was statistically significant （P〈O.O5）.Conclusion Bifid Triple Viable Capsules combined with early enteral nutrition can improve the nutritional status of patients with acute cerebral infarction,but also can improve the gastrointestinal function,and it play a adjuvant therapy role,thus it is worthy of promotion in clinic.