精准护理干预措施在改善肾肿瘤患者术后炎症因子及免疫状态的应用

Application of Precise Nursing Intervention in Improving Postoperative Inflammatory Factors and Immune Status in Patients with Renal Tumor

【目的】观测精准护理干预措施在改善肾肿瘤患者术后炎症因子及免疫状态的效果。【方法】选取2015年10月1日至2016年12月1日在本院进行肾脏肿瘤切除手术患者90例作为研究对象，按随机数法分成两组，各37例。对照组实施常规护理，观察组在常规护理基础上应用精准护理干预措施，比较分析两组护理前、后炎症因子[白细胞介素-1（interleukln-1，IL—1），血清肿瘤坏死因子（TNF-α）]、免疫状态以及肾功能指标水平。【结果】护理干预前，两组IL-1、TNF—d水平差异无统计学意义（P〉0．05）；实施护理后，两组II。一1、TNFa指标均较本组治疗前降低，且观察组下降趋势更明显，差异有统计学意义（P〈0．05）；护理后观察组的CD4^＋、CD8^＋、CD8^＋、IgA、IgG、IgM水平均明显高于对照组，差异有统计学意义（P〈0．05）。【结论】肾脏肿瘤切除术后给予精准护理干预措施能够有效降低患者机体内的炎症反应，提高自身免疫系统功能，进而改善肾功能水平，有利促进患者预后康复进程和生存质量，临床应用效果明显，值得应用推广。

[Objective]To study the effect of precise nursing intervention in improving postoperative inflammatory factors and immune status in patients with renal neoplasms. [Methods] A total of 90 cases of patients with renal tumor resection from October 2015 to December 2016 in Xiangya hospital were selected as study subjects. All of the patients were divided into two groups according to the random number methodwith 37 cases in each group. The control group was treated with routine care, and the observation group was treated with precise nursing interventions on the basis of routine nursing. The levels of interleukin-1 （II.-1）, serum tumor necrosis factor （TNF-α）, immunological status and renal function were analyzed before and after treatment. [Results]There was no significant difference in IL-1 and TNF-α levels be-- tween the two groups before treatment （ P〈0.05）. After treatment, the levels of IL-1 and TNF-α in the two groups were lower than those before treatment, and the descending trend of the observation group was more obvious than that of control group （ P %0.05）. The levels of CI）4^＋ , CD3^＋ , CD8^＋ , IgA, IgG and IgM in the observation group were signifi- cantly higher than those in the control group （ P %0.05）. [Conclusion] The precise nursing intervention can effectively reduce the inflammatory reaction in the patients after renal surgery, improve the function of the immune system and renal function, and promote the prognosis of patients with rehabilitation and quality of life. It is worthwhile to put precise nursing intervention into clinical application.