激素替代疗法与卒中

Hormone replacement therapy and stroke

激素替代疗法（hormone replacement therapy，HRT）包括给予类固醇性激素，例如雌激素单用或与孕激素联合应用，被广泛用于绝经后女性。HRT有助于缓解更年期症状，并被证实可预防骨质疏松。虽然大多数观察性研究显示HRT可降低心脑血管病风险，但随后的随机对照试验结果却与之相悖。文章从药物种类、用药途径、雌激素剂量、开始时机等方面对HRT与卒中的关系进行了综述。

Hormone replacement therapy （HRT）, involving giving sex steroid hormones such as estrogen alone or with a progestogen, is widely used in postmenopausal women. HRT helps to relieve menopausal symptoms and has also been shown to prevent osteoporosis. Although most observational studies have showed that HRT can reduce the risks of cardio-cerebrovascular diseases, the subsequent randomized controlled trials were inconsistent with the results. This article reviews the relationship between HRT and stroke from drug type, route of administration, estrogen dosage, and initiation time.