围手术期应用重组人生长激素对肠梗阻患者肠黏膜屏障的保护作用及免疫炎症反应评估

Protective effect of perioperative recombinant human growth hormone application on intestinal mucosa barrier function in patients with intestinal obstruction and the assessment of immune inflammatory response

目的:探讨围手术期应用重组人生长激素(r-hGH)对肠梗阻患者肠黏膜屏障的保护作用及对免疫炎症反应的影响。方法:选取在本院接受手术治疗的肠梗阻患者60例作为研究对象,回顾治疗方案并分为接受常规手术治疗的对照组34例、接受手术结合围术期r-hGH治疗的观察组26例。对比两组患者治疗前后血清中肠黏膜屏障指标、免疫球蛋白、炎症反应指标含量的差异。结果:治疗前,两组血清中肠黏膜屏障指标、免疫球蛋白、炎症反应指标含量的差异无统计学意义(P>0.05)。治疗后,观察组血清中肠黏膜屏障指标Endotoxin、D-Lactate、DAO的含量低于对照组,免疫球蛋白IgA、IgM、IgG的含量高于对照组,炎症反应指标IL-1、IL-6、PCT、TNF-α的含量低于对照组(P<0.05)。结论:肠梗阻患者围手术期应用r-hGH可发挥肠黏膜屏障保护作用,同时优化机体体液免疫、抑制全身炎症反应。

Objective：To explore the protective effect of perioperative recombinant human growth hormone（r-hGH）application on intestinal mucosa barrier function in patients with intestinal obstruction and the influence on the immune inflammatory response.Methods：A total of 60 patients with intestinal obstruction who underwent surgical treatment in our hospital between February 2013 and July 2013 were selected as the research subjects and divided into the control group（n=34）who received conventional surgical treatment and the observation group（n=26）who received surgery combined with perioperative rhGH treatment.The serum levels of intestinal mucosa barrier indexes,immunoglobulin and inflammatory response indicators were compared between two groups of patients before and after treatment.Results：Before treatment,differences in serum levels of intestinal mucosa barrier indexes,immunoglobulin and inflammatory response indicators were not statistically significant between the two groups of patients（P〉0.05）.After treatment,serum intestinal mucosa barrier indexes Endotoxin,D-Lactate and DAO levels in observation group were lower than those in control group,immunoglobulin IgA,IgM and IgG levels were higher than those in control group,and inflammatory response indicators IL-1,IL-6,PCT and TNF-αlevels were lower than those in control group patients（P〈0.05）.Conclusions：Perioperative r-hGH application in patients with intestinal obstruction can protect the intestinal mucosa barrier,also optimize the humoral immunity and suppress the systemic inflammatory response.