子痫前期患者肾动脉超声参数与肾损害、胎盘缺氧程度的相关性

Correlation of renal arterial ultrasound parameters with renal damage and placental hypoxia in patients with preeclampsia

目的:研究子痫前期患者肾动脉超声参数与肾损害、胎盘缺氧程度的相关性。方法:选择在本院诊断为子痫前期的56例孕妇作为研究的PE组,选择同期产检的健康孕妇作为对照组。采用彩色多普勒超声仪测定肾动脉血流参数,采用酶联免疫吸附试剂盒测定血清中肾损伤、内皮损伤指标的含量以及胎盘中缺氧所致凋亡分子的含量。结果:PE组孕妇肾内叶间动脉Vs、Vd、AT的水平显著高于对照组;PE组孕妇血清中CysC、β2-MG、sFlt-1、sEng、ET-1、AnnexinV、vWF的含量以及尿液中KIM-1、NGAL的含量均显著高于对照组且与肾内叶间动脉Vs、Vd、AT的水平呈正相关,胎盘中ROS、CytC、Caspase-3、Caspase-9的含量均显著高于对照组且与肾内叶间动脉Vs、Vd、AT的水平呈正相关。结论:子痫前期患者肾动脉血流参数的改变能够评估肾损害及胎盘缺氧的程度。

Objective：To study the correlation of renal arterial ultrasound parameters with renal damage and placental hypoxia in patients with preeclampsia.Methods：A total of 56 cases of pregnant women who were diagnosed with preeclampsia in Mianyang People＇s Hospital between May 2014 and October 2016 were selected as the PE group of the research,and healthy pregnant women who received antenatal care during the same period were selected as the control group.Color Doppler diasonograph was used to determine renal arterial blood flow parameters,and enzyme-linked immunosorbent assay kits were used to determine the contents of renal damage and endothelial injury indexes in serum as well as the contents of apoptosis molecules caused by hypoxia in placenta.Results：Renal interlobar arterial Vs,Vd and AT levels in PE group were significantly higher than those in control group;CysC,β2-MG,sFlt-1,sEng,ET-1,AnnexinV and vWF contents in serum as well as KIM-1andNGAL contents in urine of PE group were significantly higher than those of control group and positively correlated with renal interlobar arterial Vs,Vd and AT levels,and ROS,CytC,Caspase-3and Caspase-9contents in placenta were significantly higher than those of control group and positively correlated with renal interlobar arterial Vs,Vd and AT levels.Conclusions：The change of renal arterial blood flow parameters in patients with preeclampsia can assess the extent of renal damage and placental hypoxia.