贝伐单抗联合卡铂治疗非小细胞肺癌恶性胸腔积液的临床研究

Clinical study on bevacizumab combined with carboplatin therapy for malignant pleural effusion of non-small cell lung cancer

目的:研究贝伐单抗联合卡铂治疗非小细胞肺癌恶性胸腔积液对肿瘤标志物、血管新生分子、侵袭性生长分子的影响。方法:选择诊断为非小细胞肺癌合并胸腔积液的68例患者并随机分为两组,联合组患者接受贝伐单抗联合卡铂化疗,卡铂组接受卡铂化疗。治疗前及治疗后3个周期、6个周期时,检测胸腔积液中肿瘤标志物、血管新生分子、侵袭性生长分子的含量。结果:治疗后3个周期、6个周期时,两组患者胸腔积液中CEA、SCCAg、CYFRA21-1、sHLA-G、VEGF、VEGFR、PTN、MMP7、MMP10的含量显著低于治疗前,TIMP1、TIMP2的含量均显著高于治疗前且联合组患者治疗后3个周期、6个周期时胸腔积液中CEA、SCCAg、CYFRA21-1、sHLA-G、VEGF、VEGFR、PTN、MMP7、MMP10的含量均显著低于卡铂组,TIMP1、TIMP2的含量均显著高于卡铂组。结论:贝伐单抗联合卡铂治疗非小细胞肺癌恶性胸腔积液能够有效杀伤癌细胞、抑制血管新生及细胞侵袭。

Objective：To investigate the effect of bevacizumab combined with carboplatin therapy for malignant pleural effusion of non-small cell lung cancer on tumor markers,angiogenesis molecules and invasive growth molecules.Methods：A total of 68 patients who were diagnosed with non-small cell lung cancer complicated by pleural effusion in the Affiliated T.C.M Hospital of Southwest Medical University between June 2013 and August 2016 were selected and randomly divided into two groups,the combined group received bevacizumab combined with carboplatin chemotherapy,and the carboplatin group received carboplatin chemotherapy.Before treatment as well as 3cycles and 6cycles after treatment,the contents of tumor markers,angiogenesis molecules and invasive growth molecules in pleural effusion were examined.Results：3cycles and 6cycles after treatment,CEA,SCCAg,CYFRA21-1,sHLA-G,VEGF,VEGFR,PTN,MMP7 and MMP10contents in pleural effusion of both groups of patients were significantly lower than those before treatment while TIMP1 and TIMP2contents were significantly higher than those before treatment,and CEA,SCCAg,CYFRA21-1,sHLA-G,VEGF,VEGFR,PTN,MMP7 and MMP10contents in pleural effusion of combined group were significantly lower than those of carboplatin group while TIMP1 and TIMP2contents were significantly higher than those of carboplatin group.Conclusion：Bevacizumab combined with carboplatin therapy for malignant pleural effusion of non-small cell lung cancer can effectively kill cancer cells,and inhibit angiogenesis and cell invasion.