PDCD-1基因rs 2227982多态性与强直性脊柱炎易感性的Meta分析

PDCD-1 rs 2227982 polymorphism and susceptibility to ankylosing spondylitis:A Meta-analysis

目的采用Meta分析的方法评价程序性细胞死亡因子-1(PDCD-1)基因rs 2227982多态性与强直性脊柱炎(AS)易感性的相关性。方法计算机检索PubMed、Embase、CBM、CNKI、VIP和WanFang Data,查找关于PDCD-1基因rs 2227982多态性与AS相关性的病例-对照研究,检索时限均为从建库至2015年12月。由2位评价者独立筛选文献、提取资料和质量评价后,共纳入5个病例-对照研究,共计968例AS患者和985例非AS对照,采用Stata 12.0软件进行Meta分析。结果 Meta分析结果显示,T等位基因人群AS发病风险高于C等位基因人群(OR=1.74,95%CI1.48~2.06,P<0.001);TT基因型人群AS发病风险高于CC基因型人群(OR=1.88,95%CI 1.30~2.73,P=0.001);TT+CT基因型人群AS发病风险高于CC基因型人群(OR=2.29,95%CI 1.65~3.18,P<0.001);但TT基因型人群AS发病风险与CT基因型人群(OR=0.81,95%CI 0.55~1.19,P=0.283)和CT+CC基因型人群(OR=1.33,95%CI0.94~1.89,P=0.118)的差异无统计学意义。结论当前的证据表明,PDCD-1基因rs 2227982多态性可能会增加AS的发病风险。由于纳入研究数量的限制,该结论尚需进一步开展研究加以验证。

Objective To evaluate the association between programmed cell death factor-1 （PDCD-1） gene rs 2227982 polymorphism and the ankylosing spondylitis （AS） susceptibility by meta analysis. Methods PubMed, Em base, CNKI, VIP and WanFang Data were systematically searched to collect case-control studies with the association be tween PDCD-1 rs 2227982 polymorphism and AS susceptibility published from setting up to December, 2015. Two valua tors independently screened literature, extracted data, and assessed the quality of included studies. A total of 5 case-con- trol studies were included, involving 968 AS eases and 985 controls. Then meta-analysis was performed by using Stata 12.0 software. Results The results of meta-analysis showed that T allele carriers presented higher risk of AS than C allele carriers（OR=1. 74, 95%CI 1.48 to 2.06, P〈0. 001） , TT genotype carriers presented higher risk than CC geno- type carriers （OR=1. 88, 95%CI 1.30 to 2.73, P=0. 001）, and TT＋CT genotype carriers presented higher risk than CC genotype carriers （OR=2.29, 95%CI 1.65 to 3.18, P〈0. 001）. Compared with TT genotype carriers, no signifi- cant difference was observed in theCT genotypecarriers （OR=0.81, 95%CI 0.55 to 1.19, P=0.283） and CT＋CC genotype carriers （OR=1. 33, 95%CI 0.94 to 1.89, P=0. 118）. Conclusion Current evidence suggested that PDCD-1 rs 2227982 polymorphism might increase the susceptibility of AS. Due to limited quantity of included studies, the conclu- sion was needed to be confirmed with further studies.