妊娠期母体低甲状腺素血症与后代神经精神发育

Maternal hypothyroxinemia during pregnancy and offspring neurodevelopment

低甲状腺素(T4)血症即低T4血症,是指游离甲状腺素(FT4)降低而促甲状腺激素(TSH)水平在正常范围内,是亚临床甲状腺激素缺乏的一种现象。妊娠期母体低T4血症可以影响后代脑发育,包括对学习、认知、记忆、运动的影响,以及对精神疾病发生的影响。本文就妊娠期母体低T4血症对后代脑发育的人群研究和可能的机制进行综述,旨在为相关研究提供新思路。

Hypothyroxinemia is defined as the presence of low maternal thyroxine （T4） in the absence of thyroid-stimulating hormone （TSH） elevation,which is a kind of phenomenon of subclinical thyroid hormone deficiency.Maternal hypothyroxinemia has adverse effects on fetal neurodevelopment,such as learning,cognition,memory,motor,and the onset of neuropsychiatric diseases in progeny.We review the studies on the relationship between maternal hypothyroxinemia and fetal neurodevelopment,as well as the possible mechanisms.