乳腺癌干细胞近年的主要研究进展

Some recent progress on breast cancer stem cells

背景:随着对乳腺癌发生、发展机制的不断深入研究,乳腺癌干细胞日益受到重视。目的:对乳腺癌干细胞的特征、调控乳腺癌干细胞的相关信号通路以及乳腺癌干细胞与上皮间质转化、乳腺癌转移、肿瘤微环境、治疗抵抗等方面的主要研究进展做一综述。方法:由第一作者以"Breast cancer,Stem cells,Signaling pathway,Epithelial mesenchymal transition,Tumor microenvironment"为关键词,检索PubM ed等数据库从2001至2017年的相关文献,排除与文章研究目的无关及重复性的文章,纳入符合标准的60篇文献进行综述。结果与结论:肿瘤干细胞学说的提出解释了肿瘤转移和复发的根本原因,为肿瘤治疗提供一个新的研究思路,随着对乳腺癌干细胞的致病分子机制、特性和相关分子调控机制的深入研究,明确了乳腺癌干细胞在乳腺癌发生、发展中所扮演的角色,对靶向乳腺癌干细胞的肿瘤治疗方法的研究具有重要指导意义。

BACKGROUND： With the in-depth exploration of the mechanism of breast cancer occurrence and increasing attention has been paid to breast cancer stem cell development. OBJECTIVE： To review the main progress in the characteristics, related signaling pathways, epithelialmesenchymal transition, breast cancer metastasis and tumor microenvironment about breast cancer stem cells. METHODS： A computer-based retrieval of Pub Med database was performed in order to search relevant articlespublished from 2001 to 2017, using the keywords of ＂breast cancer, stem cells, signaling pathway, epithelialmesenchymal transition, tumor microenvironment＂. After removal of repetitive or irrelevant articles, 60 articles were finally reviewed. RESULTS AND CONCLUSION： The tumor stem cell theory explains the root cause of tumor metastasis and recurrence, and provides a new insight into the tumor treatment. With the further study on the molecular pathogenesis, characteristics and related molecular regulation mechanisms of breast cancer stem cells, the role of breast cancer stem cells is explicated in the development and progression of breast cancer, which is of great significance in the tumor treatment targeting breast cancer stem cells.