Tei指数评价曲美他嗪治疗糖尿病心肌病慢性心力衰竭的临床研究

Evaluation of the effect of trimetazidine on cardiac funcfion of patients with chronic heart failure due to diabetic cardiomyopathy by Tei index

目的探讨Tei指数评价曲美他嗪治疗对老年糖尿病心肌病(DCM)慢性心力衰竭患者心功能的影响。方法选取DCM慢性充血性心力衰竭患者47例,随机分为对照组23例和治疗组24例。对照组给予标准药物治疗,治疗组在标准药物治疗基础上给予曲美他嗪治疗。观察两组治疗前和治疗后6个月的Tei指数及脑利钠肽(BNP)的变化。结果两组治疗后BNP降低,Tei指数减小,治疗组较对照组改善更明显,差异均有统计学意义(均P<0.05)。结论 Tei指数能够评价曲美他嗪治疗对老年DCM慢性心力衰竭患者心功能的改善,有一定临床价值;BNP可作为诊断老年DCM患者心力衰竭的重要指标。

Objective To investigate the clinical value of Tei index in assessing the effect of trimetazidine on the cardiac function of patients with chronic heart failure due to diabetic cardiomyopathy.Methods Total 47 patients with chronic heart failure due to diabetic cardiomyopathy were randomly divided into treatment group（n=24）and control group（n=23）.All of the patients received conventional therapy for heart failure.The treatment group was treated by standard daily dose of trimetazidine for 6 months based on the conventional therapy.The changes of Tei index and brain natriuretic peptide（ BNP）were analyzed before and after treatment.Results The Tei index and BNP of the two groups were both decreased after treatment,and the cardiac function was significantly improved in treatment group than those in control group with statistical significance（all P〈0.05）.Conclusion Tei index is feasible for estimating trimetazidine improved cardiac function in patients with chronic heart failure due to diabetic cardiomyopathy.BNP could be an important index for diagnosing patients with chronic heart failure due to diabetic cardiomyopathy.