Pink1/Parkin介导的线粒体自噬分子机制

Advance on the Molecular Mechanism of Pink1/Parkin-Mediated Mitophagy

线粒体自噬作为一种选择性清除受损线粒体的特异性自噬类型,是细胞内线粒体的质量控制体系,其活性受多种途径调控。近年来,关于线粒体自噬的调控及其对生理、病理方面的影响受到众多研究者的关注,并获得了显著的研究成果。研究表明,人PTEN诱导激酶1(PTEN induced putative kinase 1,Pink1)/Parkin通路调控线粒体动力学过程,并介导受损线粒体的自噬性清除。PINK1/PARK2基因缺失或突变是神经退行性疾病的重要发病机制之一,其功能异常也与多种肿瘤的发生有关。该综述主要介绍了Pink1/Parkin蛋白质的生化特性、介导线粒体自噬发生的分子机制及其对细胞生物学进程的影响。

Mitophagy, the selective degradation of damaged mitochondria via autophagy dependent manner, is an important mitochondrial quality control system and regulated by a variety of pathways. In recent years, the regulation of mitophagy and its effects on physiology and pathology have been attracted increasing attention and obtained remarkable progress. The present evidence indicates that Pink1/Parkin pathway regulates mitochondrial dynamics and mediates the removal of damaged mitochondria via autophagy. Defects in PINK1/PARK2 are the main cause of Parkinson’s disease. In addition, the dysfunction of Pink1/Parkin may have a role in the development of cancer. This review discribes the biochemical characteristics of Pink1/Parkin, highlights the molecular mechanism of mitopagy and its impact on the cellular processes.