NuMA蛋白质的生物学作用

The Biological Functions of NuMA Protein

NuMA(nuclear mitotic apparatus)是一个高分子量的细胞核有丝分裂器蛋白。自1980年发现至今已有30多年的历史。研究发现,NuMA对细胞有丝分裂过程中纺锤体的形成和结构维持、细胞分裂后期核重组均发挥重要作用。NuMA的过表达与恶性肿瘤发生发展相关,NuMA的降解将导致细胞分裂异常及细胞核骨架的分解。该文将对NuMA的表达及定位、可变剪接体、相互作用蛋白质及其在有丝分裂、不对称分裂及核移植胚胎早期发育等过程中的功能进行了系统综述。

Nuclear mitotic apparatus（NuMA） is a nuclear mitotic apparatus protein with high molecular weight. It has been more than 30 years since it was discovered at the first time in 1980. It has been found that NuMA plays important roles in mitotic spindle organization and maintenance, as well as post-mitotic nuclear reorganization. Moreover, overexpression of NuMA was closely related to the occurrence and development of multiple malignant tumors and the degradation of NuMA could lead to abnormal cell division and the decomposition of nuclear scaffold. In current paper, the expression and localization, alternatively splicing isoforms and interaction proteins of NuMA, as well as the progress in functions of NuMA in mitosis, asymmetric division and early development of nuclear transfer embryos were systematically reviewed.