CT对心外膜脂肪体积与升主动脉弹性的相关性

Correlation Between Epicardial Adipose Tissue and Ascending Aortic Stiffness Measured by CT

目的运用CT测量结果探讨心外膜脂肪体积与升主动脉弹性的相关性,借以通过心外膜脂肪(EAT)体积早期评估升主动脉病变。资料与方法收集2016年1-9月在锦州医科大学附属第一医院行冠状动脉CT血管造影和冠状动脉造影检查的疑似冠心病患者169例,并根据有无冠状动脉硬化分为对照组(60例)和研究组(109例)。研究组按冠状动脉粥样硬化程度评分分为轻微组、轻度组、中度组和重度组。以文献记载EAT体积的阈值107.2 cm^3为界分为暴露组,其余为非暴露组。测量并计算EAT体积及升主动脉弹性值。分析EAT体积与升主动脉弹性值的相关性以及EAT体积与冠状动脉粥样硬化关系。结果对照组EAT体积与升主动脉弹性值无相关性(r=-0.156,P>0.05);轻微、轻度、中度、重度组EAT体积与升主动脉弹性值间均呈负相关(r=-0.378、-0.340、-0.514、-0.459,P<0.05);EAT体积是升主动脉弹性值的独立影响因子(β=-0.009,t=-2.653,P<0.05);暴露组发生冠心病的风险是非暴露组的9.318倍。结论冠心病患者的EAT体积与升主动脉弹性有明显的相关性。EAT体积的评价能为临床早期预测冠心病患者升主动脉病变的发生提供有效参考。

Purpose To explore the relationship between epicardial adipose tissue（EAT）volume and ascending aortic stiffness by CT, so as to early evaluate the lesions of ascending aortic by measuring EAT. Materials and Methods 169 patients with suspected coronary artery disease who underwent coronary CT angiography and coronary angiography in First Affiliated Hospital of Jinzhou Medical University from January 2016 to September 2016 were enrolled. According to the presence of coronary atherosclerosis or not, the patients were divided into research group（109 cases） and control group（60 cases）. The research group were further divided into slight, mild, moderate and severe group according to the Gensini score of coronary atherosclerosis. The recorded threshold of EAT volume was 107.2 cm^3. The patients with EAT volume higher than 107.2 cm^3 belonged to the exposure group, and the rest belonged to the non exposure group. The EAT volume and ascending aortic stiffness were measured, and the relationship between them was assessed. The relationship between EAT volume and coronary atherosclerosis was also analyzed. Results In the control group, there was no correlation between EAT volume and ascending aortic stiffness（r =-0.156, P〉0.05）. However, there were negative correlations between EAT volume and ascending aortic stiffness in slight, mild, moderate and severe group（r=-0.378,-0.340,-0.514 and-0.459, P〈0.05）. The EAT volume was an independent risk factor of ascending aortic stiffness（β=-0.009, t=-2.653, P〈0.05）. The incidence of CAD in the exposure group was 9.318 times of that in the non exposure group. Conclusion There is obvious correlation between EAT volume and ascending aortic stiffness in patients with CAD. The evaluation of EAT volume can provide an effective reference for the early prediction of ascending aortic lesions in patients with CAD.