不同剂型止嗽散治疗喘息型支气管炎疗效分析

Analysis of Therapeutic Effect on Asthmatic Bronchitis Treated by Different Dosage Forms of Zhisou Powder

目的:观察止嗽散不同剂型治疗喘息型支气管炎的临床疗效,分析疗效差异的原因。方法:70例随机分为两组各35例。用止嗽散为基础方分别制备汤剂和冲剂,观察组用冲剂治疗,对照组用汤剂治疗。观察两组治疗效果,检测药物有效成分的提取率,分析不同剂型治疗喘息型支气管炎的疗效差异的原因。结果:观察组临床治愈率和显效率显著高于对照组(P<0.05)。冲剂紫菀酮、芍药苷及总黄酮有效成分提取率均显著高于汤剂(P<0.05)。结论:止嗽散冲剂颗粒较汤剂治疗喘息型支气管炎效果好,这可能与冲剂中药物有效成分更高有关。

Objective： To study the clinical effect and mechanism of Zhisou Powder prepared by different ways in the treatment of asthmatic bronchitis. Method ： 70 patients with asthmatic bronchitis were randomly divided into two groups, 35 cases in each group.The observation group were treated with Zhisou powder mixed with water before administration while the control group were treated with decoction made from Zhisou powder. The effect of both groups was observed. The extract rate of effective composition was detected.The mechanism of Zhisou powder prepared by different ways in the treatment of asthmatic bronchitis was analyzed. Result： The clinical curative rate and effective rate in the observation group were significantly higher than those in the control group（P〈O.05）.The extract rate of shionone, paeoniflorin and total flavones in observation group were signific, antly higher than those in control group.Conclusion： Compared with traditional Chinese medicine decoction, Zhisou powder mixed with water before administration is more effective in treating asthmatic bronchitis in terms of relieving asthma, cough and expectoration, which may be related to preparation process changing the extract rate of effective composition in granules.