摘要
目的研究神经调节肽U(neuromedin U,NMU)在喉癌淋巴结转移中的作用,为淋巴结转移的早期诊断提供新的分子标志物。方法收集锦州医科大学附属第一医院耳鼻咽喉头颈外科2013年1月~2015年12月间共120例喉癌患者标本,免疫组化方法分析原发灶及淋巴结组织中NMU的表达,组织芯片技术分析NMU在喉癌组织中的表达。结果 NMU在转移组喉癌原发灶和淋巴结中的表达明显高于非转移组,与肿瘤的N分级相关而与T分级无明显相关性。结论 NMU在伴转移的喉癌组织中表达明显增高,可能成为预测淋巴结转移的分子标志物。
OBJECTIVE To evaluate the effect of neuromedin U（NMU） in lymph node metastasis of laryngocarcinoma and provide a new biomarker of metastasis. METHODS Samples of 120 cases of laryngocarcinoma were collected from the Otolaryngology Department of the First Affiliated Hospital of Jinzhou Medical University from 2013 to 2015. Patients were divided into two groups： metastasis group and non-metastasis group. Immunohistochemistry was performed to analyze the NMU expression in primary tumor and lymph node. An independent tissue microassay was used to analyze the relationship between NMU expression and T, N stages. RESULTS Expression of NMU in metastasis group was higher than that in non-metastasis group, NMU was positively correlated with N stages, but not with T stages. CONCLUSION The expression of NMU is higher in metastasis tissue of laryngocarcinoma, It could be used as a biomarker of lymph node metastasis of laryngocarcinoma.
出处
《中国耳鼻咽喉头颈外科》
CSCD
2017年第7期340-342,共3页
Chinese Archives of Otolaryngology-Head and Neck Surgery
基金
辽宁省科技厅自然科学基金计划面上项目(201602298)
关键词
喉肿瘤
淋巴结
神经调节肽u
Laryngeal Neoplasms
Lymph Nodes
neuromedin U
