穿心莲总黄酮对实验性冠状动脉血栓性心肌...

ANTITHROMBOGENIC EFFECTS OF FLAVONE FROM ANDROGRAPHIS PANICULATA IN THE PREVENTION OF MYOCARDIAL INFARCTION

本文观察穿心莲总黄酮(TFAP)对实验性冠状动脉血栓形成致急性心肌梗塞的预防作用。结果:TFAP使预处理犬的血小板聚集性降低,TXB_2含量降低;而血浆6-酮-PGF_1α明显升高,血小板cAMP也升高。提示TFAP可抑制TXA_2的产生,促进血管壁内皮PCI_2的生成与释放,并有促纤维蛋白溶解作用,从而抑制血小板聚集,达到防止血栓形成及急性心肌梗塞。

The left anterior descending coronary artery of 16 dogs was handled for the formation of thrombus, eight dogs had been treated beforehand with an extract of Andrographis paniculata(TFAP) and an equal number of dogs in the control group received saline. In the control group, the epicar dial ST segments started to elevate at about 15 minutes after handling, platelet aggregation rate and plasma TXB_2 increased rapidly, whereas 6 keto-PGF_(1α) remained stable. Platelet cCMP rose continously, however, platelet cAMP rose only at 60 minutes. Histological results confirmed the occurrence of arterial thrombus and myocardial necrosis. In the pretreated group, by contrast, there was no elevation of ST segment, while plasma 6-keto-PGF_(1α) and platelet cAMP increased, the increase of TXB_2 and aggregation of platelets were inhibited, and no thrombosis and myocardial infarction were induced. These data suggest that TFAP may promote the synthesis of PGI_2, inhibit the production of TXA_2, stimulate the synthesis of cAMP in platelets, prevent aggregation of platelets, and thereby preventing the formation of thrombi as well as the development of myocardial infarction.