4-氟-1-萘酚的合成

Synthesis of 4-Fluoro-1-naphthalenol

以1-氟萘为起始原料,经卤代、硼酸基团取代卤素以及硼酸基水解3步反应合成重要的医药化工中间体,即标题化合物。该合成方法未见文献报道,原料易得、成本低廉且收率较高。

1-Fluoronaphthalene as a starting material, the important intermediate of 4-fluoro-l-naphthalenol was synthesized via halogen substituted ,boric acid group substituted halogen and the hydrolysis of boric acid group reactions.No reports on the synthe- sis of this compound was found in the literature, and the raw materials was easy to he found, low cost, the total yield was higher.