稳心草的化学成分及药理作用研究进展

Research progress on chemical constituents of Hypericum attenuatum and their pharmacological activities

稳心草为藤黄科金丝桃属植物Hypericum attenuatum,在我国植物资源广泛,为我国民间常用中草药,具有解毒消炎、止血生肌、调经活血等功效,文献记载民间用之治疗烫伤、多汗症,特别是在我国东北地区民间常用其全草代茶饮用可治疗心脏病,具有很大的药用开发价值。现代研究表明,稳心草含有黄酮类、挥发油及间苯三酚衍生物等成分,具有抗心律失常、抗心肌缺血、抗肿瘤、抗抑郁、抑菌等药理作用。综述其化学成分及药理作用研究进展,以期为稳心草的临床应用、质量控制及新药研发提供参考。

Hypericum attenuatum is a Guttiferae Hypericum Linn. plant, which is a folk commonly used drug. H. attenuatum has great medical development value of detoxicating, diminishing inflammation, stopping bleeding, promoting tissue regeneration, regulating menstruation, activating blood, and so on. It was used for empyrosis, hyperhidrosis, especially heart disease in Northeast area of China from the folk records. Modern research shows that it has flavonoids, volatile oils, and phloroglucinol derivative; And it has anti-arrhythmia, antimyocardial ischemia, antitumor, antidepression, antibacterial, and other pharmacologic actions. The recent progress in the studies of the constituents and their pharmacological activity of this plant is reviewed in this paper in order to provide reference for clinical application, quality control and drug discovery.