阿奇霉素在小儿支原体肺炎治疗中的应用方法研究进展

Application Progress of Azithromycin in Treating Pediatric Mycoplasma Pneumonia

目的综述阿奇霉素在小儿支原体肺炎的临床治疗中的应用方法。方法分析国内外文献和相关资料中相关小儿支原体肺炎的传统治疗方法,对比阿奇霉素治疗法与传统疗法的区别,分析阿奇霉素常规疗法、序贯疗法和联合疗法的效果。结果临床以往选用红霉素治疗小儿支原体肺炎,但随着研究深入发现其无法将支原体完全清除,且患儿胃肠道反应较为强烈,长时间使用会损害患儿的肝脏功能,以及诱发静脉炎和血管痉挛。阿奇霉素是大环内酯抗生素,具有特殊的药代动力学,目前在小儿支原体肺炎的临床治疗中被广泛应用,且临床疗效较佳。结论小儿支原体肺炎应用阿奇霉素的研究目前已有重大进展,特别是序贯治疗被广泛应用后,治愈率显著提升。但由于发病机制复杂,单一的疗法或药物难以有效改善病情,故应当根据实际情况妥善处理。

Objective To summarize the clinical application of azithromycin in the treatment of pediatric mycoplasma pneumonia. Methods The traditional treatment methods of pediatric mycoplasma pneumonia were found out through analyzing the domestic and foreign literature and related data. The difference between azithromycin and traditional method was compared, and the effects of routine therapy , sequential therapy and combination therapy were analyzed . Results Erythromycin was used in the treatment of pediatric mycoplasma pneumonia, but with the in-depth study found that it could not completely remove mycoplasma, and children had strong gastrointestinal response, but prolong use could damage the liver function of children, and induced phlebitis and vasospasm. Azithromycin was macrolide antibiotic, it had special pharmacokinetics. It was widely used in the clinical treatment of pediatric mycoplasma pneumonia, and its clinical efficacy was better. Conclusion The use of azithromycin in children with mycoplasma pneumonia has made significant progress. In particular, sequential treatment has been widely used, and the cure rate of children is significantly improved. However, because of the complicated pathogenesis, it is difficult for single therapy or drugs to improve the condition of disease, so the treatment should be carried out according to the actual situation.