羟考酮预防瑞芬太尼静脉麻醉术后痛觉过敏临床研究

Clinical Study of Oxycodone for Prventing Hyperalgesia After Remifentanil Intravenous Anesthesia

目的探讨羟考酮预防瑞芬太尼静脉麻醉术后痛觉过敏的临床效果。方法选择医院2016年1月至12月收治的实施瑞芬太尼静脉麻醉的手术患者68例,随机均分为两组,均于术中静脉滴注瑞芬太尼维持麻醉,对照组患者与观察组患者分别在手术结束前10 min给予芬太尼和羟考酮预防术后痛觉过敏。比较两组患者的术后恢复情况、疼痛视觉模拟评分及不良反应。结果观察组患者自主呼吸恢复时间、术后苏醒时间及拔除喉罩时间均明显短于对照组,差异有统计学意义(P<0.05);观察组患者拔除喉罩时和拔除喉罩后30 min疼痛视觉模拟评分均显著低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为5.88%,低于对照组的11.76%,但差异无统计学意义(P>0.05)。结论羟考酮预防瑞芬太尼静脉麻醉术后痛觉过敏效果明显,且不良反应相对较少,值得临床推广。

Objective To investigate the clinical effect of oxycodone for prventing postoperative hyperalgesia after remifentanil intravenous anesthesia. Methods Totally 68 patients treated with remifentanil intravenous anesthesia admitted to our hospital in 2016 were randomly divided into the two groups. During operation,the two groups were given Remifentanil intravenous infusion for maintenance anesthesia.10 min before the end of the operation,patients in the control group and the observation group were given fentanyl and oxycodone for preventing postoperative hyperalgesia. The postoperative recovery,VAS score and adverse reactions were compared between the two groups. Results The spontaneous breathing recovery time,postoperative recovery time and laryngeal mask extraction time in the observation group were significantly shorter than those in the control group（ P〈0. 05）,The VAS scores at laryngeal mask was removed and 30 min after it was removed in the observation group were significantly lower than those in the control group（ P〈0. 05）,the incidence rate of adverse reactions in the observation group was 5. 88%,which was lower than 11. 76% in the control group,but the difference was not significant（ P〉0. 05）. Conclusion The clinical effect of oxycodone for prventing postoperative hyperalgesia after remifentanil intravenous anesthesiais is good,with less adverse reactions,it is worthy of clinical promotion.