抗菌肽RISE-AP12联合电针治疗正畸后疼痛临床评价

Clinical Evaluation of Antibacterial Peptide RISE-AP12 Combined with Electroacupuncture for Treating Pain After Orthodontic

目的观察抗菌肽RISE-AP12联合电针治疗正畸后疼痛的临床疗效及安全性。方法选择2015年3月至2016年1月医院收治的正畸患者80例,按随机数字表法分为观察组和对照组,各40例。两组患者均佩戴自锁托槽或传统直丝托槽行正畸矫正,术后均采用电针治疗,选取局部阿是穴及上关穴、下关穴、听宫穴、听会穴、四白穴、合谷穴、列缺穴。观察组在此基础上给予抗菌肽RISE-AP12含漱,每日3次。两组患者均治疗5 d。结果观察组初发疼痛时间晚于对照组,疼痛持续时间短于对照组,各个时间点疼痛视觉模拟(VAS)评分及牙科焦虑评分均低于对照组(P<0.05);正畸后,两组患者龈沟液中肿瘤坏死因子-α(TNF-α)、白细胞介素1β(IL-1β)的表达水平与正畸前相比呈上升趋势,各个时间点表达水平均高于正畸前,且观察组表达水平均低于对照组(P<0.05);观察组患者口腔黏膜溃疡发生率明显低于对照组患者(P<0.05);两组患者治疗过程中均出现口干、恶心、食欲不振,总发生率相当(P>0.05)。结论抗菌肽RISE-AP12联合电针治疗正畸后疼痛疗效显著,可降低患者牙科焦虑评分及口腔溃疡发生率,安全性较好,其机制可能是通过降低患者龈沟液中炎性因子的表达发挥作用。

Objective To observe the clinical efficacy and safety of antibacterial peptide RISE-AP12 combined with electroacupuncture for treating pain after orthodontic. Methods Totally 80 orthodontic patients from March 2015 to January 2016 in our hospital were randomly divided into the observation group and the control group,40 cases in each group. The two groups were treated with self-ligating bracket or traditional slot preadjusted orthodontic appliance line,then the patients were treated with electro-acupuncture,the points of local Ashi,Shangguan,Xiaguan,Tinggong,Tinghui,Sibai,Hegu,Lieque were selected,on this basis,the observation group was given antibacterial peptide RISE-AP12 gargle,3 times a day. The two groups were treated for 5 d. Results The initial pain time of the observation group was later than that of the control group,the pain duration was shorter than that of the control group,and the VAS score and the dental anxiety score at each time point were lower than those in the control group（ P〈0. 05）. After treatment,the expression levels of TNF-α and IL-1β in gingival crevicular fluid in the two groups were increased,the expression levels of each time point were higher than those before treatment,and the observation group were lower than the control group（ P〈0. 05）. The incidence rate of oral ulcers in the observation group was lower than that in the control group（ P〈0. 05）. The xerostomia,nausea and loss of appetite occurred in the two groups,and the total incidence rate was similar（ P〉0. 05）. Conclusion Antibacterial peptide RISE-AP 12 combined with electroacupuncture for treating pain after orthodontic has good effect and safety,it can reduce the patient ＇ s dental anxiety score and the incidence rate of oral ulcers,its mechanism may be played by reducing the expression of inflammatory factors in gingival crevicular fluid.