多塞平3mg治疗单纯末段失眠临床观察

To Observe Effects of Low-dose Doxepin 3 mg for Terminal Insomnia

目的:观察对比多塞平(3 mg)和艾司唑仑治疗末段失眠效果。方法:60例末段失眠患者随机分为治疗组和对照组。治疗组:多塞平片3 mg/次,每日或隔日用药。对照组:艾司唑仑片1~2 mg/次,服药方法同前。2组患者治疗观察4周。结果:2组睡眠因子评分在治疗后较治疗前有显著减少(P<0.05);2组间主要睡眠因子评分对比没有显著性差异(P>0.05)。结论:小剂量多塞平治疗末段失眠有效。

Objective： To observe effects of low-dose doxepin （3 mg ） for the treatment terminal insomnia. Methods ： 60 cases of patients withl terminal insomnia were randomly divided into two groups. Treatment group 30 cases, doxepin 3 mg/times oral, once a day or other day. Control group 30 cases, the estazolam tablet 1 mg/times, medication method ibid. Two groups of the patients were observed for 4 weeks. Results： Sleep factors score were signifi- cantly decreased （P 〈 0. 05） after treatment of two groups than before, There was no significant difference between the two groups of the main sleep factors score comparison （ P 〉 0.05 ） . Conclusion： low-dose doxepin （ 3 mg） is effective in the treatment of the terminal insomnia.