莫西沙星序贯疗法根除Hp感染效果观察

Observation of the efficacy of moxifloxacin-based sequential therapy to eradicate helicobacter pylori infection

目的 研究由埃索美拉唑联合莫西沙星、阿莫西林、克拉霉素组成的序贯疗法根除幽门螺杆菌（Hp） 的疗效.方法 将92例Hp阳性的患者随机分为两组.治疗组采用前5 d应用埃索美拉唑20 mg加阿莫西林1 000 mg,2次/d,后5天使用埃索美拉唑20 mg加克拉霉素500 mg,2次/d;莫西沙星400 mg qd.对照组采用埃索美拉唑20 mg加阿莫西林1 000 mg加克拉霉素500 mg,2次/d共7d.4周后复查内镜和呼气试验.结果 治疗组幽门螺杆菌根除率93.6%,对照组82.2%,两组差异有统计学意义（P〈0.05）;治疗组和对照组不良反应发生率差异无统计学意义.结论 含莫西沙星的序贯疗法Hp根除率高,副反应低.

Objective To evaluate the efficacy of ten days sequential therapy consisted of Moxifloxacin,amoxicillin,Clarithromycin and Esomeprazole in Helicobacter pylori infection.Methods Ninty-two patients with H.pylori-infected were randomly divided into two groups.Treatment group received 5 days esomeprazole 20mg and amoxicillin 1000mg,twice a day;The follow-up 5 days received esomeprazole 20mg,clarithromycin 500mg,twice a day and moxifloxacin 400mg one time a day.Control group received 7 days therapy consisted of esomeprazole 20mg,amoxicillin 1000mg and clarithromycin 500mg twice a day.All patients were observed by 13-C urea breath test and endoscopy in fourweeks after treatment.Results The eradication rates of the treatment group and the control group were 93.6% and 82.2% respectively（P〈0.05）;There were no significant differences in the adverse event rates of two groups.Conclusion Moxifloxacin-based sequential therapy is effective and lower side-effects in eradication of Helicobacter pylori infection.