事件相关电位P300在血管性轻度认知功能障碍中的应用

Application of event-related potentials P300 in vascular mild cognitive impairment

目的 探讨事件相关电位P300在血管性轻度认知功能障碍（vascular mild cognitive impairment,VaMCI）中的应用价值.方法 分别选取无痴呆表现的急性脑梗死组患者40例、原发性高血压组患者60例,并选取健康志愿者40例为健康对照组,测定三组受试者MOCA评分分值、P300峰电位潜伏期、波幅、N200-P300波间期.结果 与健康对照组相比,脑梗死组和原发性高血压组患者MOCA分值减低,P300潜伏期延长,N200-P300波间期,以脑梗死组变化更明显,差异均具有统计学意义;P300波幅较健康对照组延长,但脑梗死组具有统计学意义,原发性高血压组无统计学意义.与原发性高血压组比较,脑梗死组MOCA分值减低,P300潜伏期延长,波幅延长,N200-P300波间期延长,差异有统计学意义.结论 原发性高血压但未发生中风的患者、无痴呆表现急性脑梗死患者存在认知功能的损害,P300的测定有利于早期诊断血管性认知功能障碍患者;为干预治疗前移提供重要依据.

Objective To investigate the value of P300 in vascular mild cognitive impairment（vascular mild cognitive impairment,VaMCI） in.Methods Patients with acute cerebral infarction group selected performance without dementia who were 40,60 hypertension patients and 40 healthy volunteers selected human normal control group,three groups of subjects MoCA score measured value,P300 peak potential latency volatility,N200-P300 wave interval.Results Compared with normal control group,patients with cerebral infarction and hypertension patients MOCA score lower,P300 latency,N200-P300 wave interval,CI group to change more obvious,the differences were statistically significant;P300 volatility than normal control groups,but statistically significant cerebral infarction group,hypertension group was not statistically significant.Compared with patients with hypertension,cerebral infarction group MOCA score lower,P300 latency,amplitude extended,N200-P300 wave interval prolongation,the difference was statistically significant.Conclusion Patients with hypertension but no occurrence of stroke,dementia-free performance there is no damage cognitive function in patients with acute cerebral infarction,measuring P300 facilitates early diagnosis of vascular cognitive dysfunction;provide an important basis for the intervention forward.