启东地区乙型肝炎病毒基因型分布特点及与临床指标的关系

Correlation between HBV genotypes and clinical manifestations in Qidong

目的 探讨启东肝癌高发区乙型肝炎病毒（HBV）基因型在不同肝病中的分布以及与临床指标的关系.方法 以372例HBV相关性肝病患者为研究对象,检测其血清中HBsAg、HBeAg、抗-HBe、HBV DNA载量和HBV基因型,进行分析研究.结果 HBV基因型以C 型为主,占95.70%,B 型占4.30%,未检测到其他基因型.C、B两种基因型患者在性别、年龄、HBeAg阳性率和HBVDNA载量上均无统计学差异（P〉0.05）,C型血清转换率显著低于B型（χ2=18.20,P=0.000）.ASC组C基因型占比显著低于CHB、HCC组（χ2=3.916,P=0.048;χ2=9.783,P=0.002）,CHB、HCC两组相比差异无统计学意义（χ2=0.420,P=0.517）.结论 启东地区HBV 基因型有B、C两种,且以C 型为主.C基因型与患者性别、年龄、HBeAg表达以及HBV病毒载量无关,与较严重病情相关.

Objective To investigate the distribution of HBV genotypes in Qidong and the correlation with clinical manifestations.Methods Serum samples of 372 patients suffered from HBV related liver diseases were collected.HBsAg,HBeAg,anti-HBe,HBV DNA and HBV genotypes were detected to analysis the correlation between HBV genotypes and clinical manifestations.Results C genotype was found to be predominant as 95.70%,another was B genotype（4.30%）.No other genotypes were found in this study.There were no significant differences of sex,age,HBeAg expression and HBV DNA level between the two genotypes（P〉0.05）.HBeAg serum conversion rate of C genotype was significantly lower than that of B genotype（P〈0.001）.The proportion of C genotype in ASC group exhibited significantly lower than that in CHB and HCC groups（P〈0.005）.There was no significant difference of genotype distribution between HCC and CHB groups（P〉0.05）.Conclusion There are B and C genotypes prevalent in Qidong,and C is significantly predominant.No significant differences of sex,age,HBeAg expression and HBV DNA level were showed between B and C.Genotype C may be related with more severe liver diseases.