母胎界面的免疫-内分泌调控对早期妊娠影响的研究进展

The progress of the effect of immune-endocrine modulation at the maternal-fetal interface on early pregnancy

妊娠是一种同种异体移植,成功妊娠的关键是母胎界面的免疫-内分泌交互调控能够顺利同步进行。而孕酮、雌二醇、人绒毛膜促性腺激素等早孕期重要激素可调控母胎界面的免疫反应。本文在既往研究认识的基础上,围绕母胎界面重要的免疫功能细胞,阐明在早孕期激素对于母胎免疫耐受的形成、滋养细胞的入侵及胎盘形成的影响。为反复自然流产、先兆子痫、胎儿宫内生长受限等疾患的防治提供激素治疗的新思路。

Pregnancy is an example of the natural allogeneic transplantation. The success of pregnancy depends mostly on a successful immune-endocrine cross-modulation at the maternal – fetal interface. Hormones have important effect on early pregnancy including progesterone, estradiol and human chorionic gonadotrop in play essential roles in the immune crosstalk at the maternal-fetal interface. This review focuses on the immunomodulatory effect of these hormones during early pregnancy on the establishment of maternal-fetus immune tolerance, invasion of trophoblastic cells and formation of placenta. The present review will provide important insights into novel therapeutic strategies of the recurrent spontaneous miscarriage, pre-eclampsia and intrauterine growth restriction.