妊娠期短PR间期与甲状腺激素水平的关系

The relationship of short PR interval during pregnancy and the level of thyroid hormone

目的探讨妊娠期短PR间期发生率以及与甲状腺激素水平的关系。方法选取2016年1~12月在北京市顺义区妇幼保健院(以下简称"我院")产检孕妇8645例为研究组,同期我院体检中心健康检查的未孕女性8650例为对照组,行心电图检查。将短PR间期孕妇分为三组:妊娠早期组(<14周)、妊娠中期组(14~<28周)、妊娠晚期组(≥28周),分别检测TSH、FT3、FT4、TT3、TT4。结果研究组妊娠期短PR间期发生率为1.504%,对照组为0.358%,两组比较差异有高度统计学意义(P<0.01)。各组间短PR值、TSH、FT3、FT4、TT3、TT4比较,差异有高度统计学意义(P<0.01)。TSH:妊娠早期组与妊娠中期组比较,差异无统计学意义(P>0.05);妊娠早期组与妊娠晚期组、妊娠中期组与妊娠晚期组比较,差异有统计学意义(P<0.05)。各组间短PR值、FT3、FT4、TT3、TT4:妊娠早期组与妊娠中期组、妊娠晚期组比较,差异有高度统计学意义(P<0.01);妊娠中期组与妊娠晚期组比较,差异有高度统计学意义(P<0.01)。结论妊娠期短PR间期发生率明显高于非妊娠女性。临床可通过监测甲状腺激素水平变化和短PR间期发生情况,结合临床症状,有效预防心律失常的发生,对于提高妊娠期短PR间期女性的安全性有重要的临床意义。

Objective To investigate the incidence of the short PR interval and relationship with the level of thyroid hormone during pregnancy. Methods From January to December 2016, in Shunyi Maternal and Children Health Care Hospital in Beijing City（ ＂our hospital＂ for short）, 8645 cases of pregnant women and 8650 cases of non-pregnant women from physical examination were performed an electrocardiogram as study group and control group. The pregnant women with the short PR interval were divided into three groups according to different gestational age： early pregnancy group（14 weeks）, mid pregnancy group（14-28 weeks） and late pregnancy group（≥28 weeks）. TSH, FT3, FT4, TT3,TT4 were tested. Results The incidence of short PR interval in pregnant women was 1.504%, and incidence of control group was 0.358%, the difference was statistically significant（P〈0.01）. They were statistically significant in short PR interval, TSH, FT3, FT4, TT3 and TT4 among groups（P〈0.01）. TSH： there was no significant difference between early pregnancy group and mid pregnancy group（P〈0.05）. There were significant difference between early pregnancy group and late pregnancy group, mid pregnancy group and late pregnancy group（P〈0.05）. Short PR interval, FT3, FT4, TT3 and TT4： there were significant difference between early pregnancy group and mid pregnancy group, early pregnancy group and late pregnancy group（P〈0.01）. There was significant difference between mid pregnancy group and late pregnancy group（P〈0.01）. Conclusion The incidence of short PR interval in pregnant women is significantly higher than that of healthy non-pregnant women. The thyroid hormone level and the short PR interval can be monitored by clinical observation. It can prevent the occurrence of arrhythmia by combining clinical symptoms effectively. It is important clinical significance to improve the safety of women with short PR interval during pregnancy.