基质金属蛋白酶-10在肺癌中作用的研究进展

Research progress of matrix metalloproteinase-10 in lung cancer

肺癌已成为癌症死因的首位,肺癌的生长、发展及转移必须要降解细胞外基质和基底膜,而起主要作用的是基质金属蛋白酶(MMPs)。MMP-10是MMPs的其中一种,有研究表明,MMP-10对肺癌的发生、发展及转移起着重要的作用。该文就MMP-10在肺癌中作用的研究进展作一综述。

Lung cancer has become the first leading cause of cancer death. Degradation of the extracellular matrix and the basement membrane,which depends on the matrix metalloproteinases（ MMPs） is necessary for the formation,growth and metastasis of lung cancer. Many studies have confirmed that MMP-10,one of the MMPs,plays an important role in the above developing processes of lung cancer. In this paper,we review the research progress of MMP-10 in lung cancer.