注射用薏苡仁油对大肠癌术后患者免疫功能及无进展生存期的影响

Effects of Coix Seed Oil for Injection on Immune Function and Progression-free Survival Time of Post-operation Patients with Colorectal Cancer

目的:探讨注射用薏苡仁油对大肠癌术后患者免疫功能和无进展生存期的影响。方法:将118例大肠癌术后患者随机按数字表法分为对照组和观察组,每组各59例。对照组给予FOLFOX4方案化疗,观察组在对照组基础上加用注射用薏苡仁油静脉滴注,共治疗6个疗程。疗程结束后每2个月对患者进行1次随访。观察记录两组患者无进展生存期(progression-free survival,PFS)和生存率,评价生存质量,检测T淋巴细胞亚群、血清免疫球蛋白G(Immunoglobulin G,IgG)、IgA、IgM及癌胚抗原(carcino-embryonic antigen,CEA)、CA125、结肠癌特异性抗原-3(colon cancer specific antigen-3,CCSA-3)水平,进行不良反应评估。结果:观察组PFS长于对照组,两组比较,差异有统计学意义(P<0.01);观察组生存率为88.14%,对照组为81.36%,两组比较,差异无统计学意义(P>0.05);治疗后观察组生存质量优于对照组,两组比较,差异有统计学意义(P<0.05);治疗后观察组患者血清CD+3、CD+4和CD+4/CD+8均高于对照组,CD+8低于对照组,两组比较,差异有统计学意义(P<0.01);治疗后观察组患者血清IgG、IgA、IgM水平高于对照组,CEA、CA125和CCSA-3水平低于对照组,且化疗导致的不良反应程度较轻,两组比较,差异有统计学意义(P<0.05)。结论:注射用薏苡仁油联合FOLFOX4治疗大肠癌术后患者,能延长PFS,提高患者免疫功能和生存质量,减轻化疗药物不良反应,降低相关肿瘤标志物水平,疗效显著。

Objective：To investigate the effect of Coix seed oil for injection on immune function and progression-free survival time of post-operation colorectal cancer patients.Methods：118 cases of colorectal cancer patients were randomly divided into control group and observation group,with 59 cases in each group of.The control group was given chemotherapy of FOLFOX4 regimen,while the observation group was treated with Coix seed oil for injection by intravenous infusion in addition to that of the control group.There was a total of 6 courses of treatment.Patients were followed up every 2 months after the course of treatment.The progression-free survival time（PFS）and survival rate were observed the quality of life was evaluated.The T lymphocyte subsets,serum immunoglobulin G（IgG）,IgA,IgM and carcinoembryonic carcino（CEA）,CA125,colon cancer specific antigen-3（CCSA-3）were detected and the adverse effects were evaluated.Results：The PFS of the observation group was significantly longer than that of the control group（P〈0.01）.The survival rate of the observation group was 88.14%,and that of the control group was 81.36%.There was no significant difference between the two groups（P〈0.05）.The quality of life of the observation group was significantly bettion group were significantly higher than those in the control group,and the CD8^＋ nwas significantly lower than that of the control group（P〈0.05）.The levels of serum IgG,IgA and IgM in the observation group were significantly higher than those in the control group,and the levels of CEA,CA125 and CCSA-3 were significantly lower than those of the control group and the adverse reactions caused by Chemotherapy was significantly less（P〈0.05）.Conclusion：The combination of Coix Seed oil for injection and FOLFOX4 in treatment of colorectal cancer patients can prolong the PFS,improve the immune function and quality of life,reduce the adverse reactions of chemotherapy drugs and reduce the level of tumor markers.