miR-608在成釉细胞瘤中的表达及意义

The Expression and Significance of miR-608 in Ameloblastoma

目的研究mi R-608在成釉细胞瘤(AB)中的表达及意义。方法利用实时茎环定量PCR方法检测mi R-608在26例人成釉细胞瘤(AB组)及17例瘤旁组织(对照组)中的表达水平,比较mi R-608在AB组与对照组,原发AB组与复发AB组,以及AB不同临床病理特征的组间差异。结果 AB中mi R-608表达水平显著下降,差异有统计学意义(P<0.05);复发组mi R-608的相对表达水平显著降低,差异有统计学意义(P<0.05)。mi R-608表达水平在不同年龄、性别和病理分型患者中均无统计学差异(P>0.05)。结论人AB组织中mi R-608表达水平显著下降,可能与该肿瘤的发生和复发相关。

Objective To study the expression and significance of miR-608 in ameloblastoma （AB）. Methods Quantitative stem-loop RT- PCR was used to detect the expression of miR-608 in 26 cases of human AB （AB group） and 17 cases of peritumoural tissues （ control group）. The differences in miR-608 levels between the control group and the AB groups, namely, primary AB and mcun＇ent AB, were evaluated. In addition, miR-608 levels in AB cases with different clinical and pathological characteristics were compared. Results The expression level of miR-608 in the AB group was significantly lower than that in the control group （P 〈 0.05 ）. Additionally, the relative expression level of miR-608 in the prima- ry AB group was significantly lower than that in the recurrent AB group （P 〈 0.05）. There were no significant differences between the miR-608 ex- pression levels with respet to age, gender, or pathological type （P 〉 0.05）. Conclusions The expression of miR-608 in human AB tissue is sig- nificantly decreased, which may be related to the recurrence of the tumor.