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miR-608在成釉细胞瘤中的表达及意义 被引量:2

The Expression and Significance of miR-608 in Ameloblastoma
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摘要 目的研究mi R-608在成釉细胞瘤(AB)中的表达及意义。方法利用实时茎环定量PCR方法检测mi R-608在26例人成釉细胞瘤(AB组)及17例瘤旁组织(对照组)中的表达水平,比较mi R-608在AB组与对照组,原发AB组与复发AB组,以及AB不同临床病理特征的组间差异。结果 AB中mi R-608表达水平显著下降,差异有统计学意义(P<0.05);复发组mi R-608的相对表达水平显著降低,差异有统计学意义(P<0.05)。mi R-608表达水平在不同年龄、性别和病理分型患者中均无统计学差异(P>0.05)。结论人AB组织中mi R-608表达水平显著下降,可能与该肿瘤的发生和复发相关。 Objective To study the expression and significance of miR-608 in ameloblastoma (AB). Methods Quantitative stem-loop RT- PCR was used to detect the expression of miR-608 in 26 cases of human AB (AB group) and 17 cases of peritumoural tissues ( control group). The differences in miR-608 levels between the control group and the AB groups, namely, primary AB and mcun'ent AB, were evaluated. In addition, miR-608 levels in AB cases with different clinical and pathological characteristics were compared. Results The expression level of miR-608 in the AB group was significantly lower than that in the control group (P 〈 0.05 ). Additionally, the relative expression level of miR-608 in the prima- ry AB group was significantly lower than that in the recurrent AB group (P 〈 0.05). There were no significant differences between the miR-608 ex- pression levels with respet to age, gender, or pathological type (P 〉 0.05). Conclusions The expression of miR-608 in human AB tissue is sig- nificantly decreased, which may be related to the recurrence of the tumor.
出处 《中国医科大学学报》 CAS CSCD 北大核心 2017年第8期724-728,共5页 Journal of China Medical University
基金 国家自然科学基金(81470758) 辽宁省教育厅科学技术研究项目(LK201626) 辽宁省大学生创新创业训练计划项目(201610159025)
关键词 成釉细胞瘤 微小核糖核酸 608 实时茎环定量 PCR 肿瘤复发 ameloblastoma miR-608 quantitative stem-loop RT-PCR tumor recurrence
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