泪液标志物在系统性疾病中的研究进展

Recent progression on tear fluid markers in systemic disease

泪液是主要由泪腺分泌的一种水样液体,是眼表的一种成分复杂的体液,可能含有数千种蛋白质及其他分子,研究已证实这些成分的改变在眼病的发生和发展中具有重要作用。泪液成分包括蛋白质、脂质及代谢物等,容易获取,不仅可以用于生物标志物,还可用于研究眼科系统性疾病的发病过程。通过测定泪液成分的变化,可能用来确定疾病发展的关键通路,为预防及治疗提供了一种新的可能。本文将到目前为止尚未确定的泪液标志物在眼科系统性疾病的应用做一简要综述。

Tear is a complex fluid mainly secreted by lacrimal gland.It is a complex body fluid,which may contain thousands of protein/peptides and other molecules.Studies have determined that the changes in the chemical compositions of tears play an important role in some diseases and their progression.Tear components including protein,lipid and metabolites,which is easy to be obtained,not only can be used for biomarkers,can also be used to study an eye the onset of systemic disease process.Measuring the changes in composition of tear may be used to determine the critical path of the disease development,provide a new possibility for prevention and treatment.This article reviews the ophthalmic applications of tear markers in the systemic disease,which has not been determined so far.