全身定位技术在全脑全脊髓调强放疗中的应用研究

Application of Whole Body Localization Technique in the Craniospinal Intensity-modulated Radiotherapy

利用全身定位体架及基部剂量计划补偿(BDPC)技术研究一种全脑全脊髓放疗方法。对本院11例中枢神经系统恶性肿瘤患者进行研究。采用全身定位体架配合头颈肩模和体膜进行患者体位固定并利用基部剂量计划补偿(Base Dose Plan Compensation,BDPC)模块进行调强优化。评价靶区适形度指数(CI)、均匀性指数(HI)和危及器官(OAR)受量及射野衔接处剂量。此种方法提高了靶区适形度和均匀性,简化了计划设计过程,提高了摆位精度并保证了重复性。射野衔接处未出现剂量冷热点,与计算值基本一致。通过本研究证明全身定位技术联合BDPC优化方法在全脑全脊髓放疗中能满足临床剂量学要求,操作简便,提高计划设计效率。

The craniospinal radiotherapy method was studied by using the whole body positioning frame and base dose plan compensation （BDPC） technique.11 patients with central nervous system malignancies in our hospital were studied. Use whole body positioning frame with the head - neck shoulder and body membrane to immobilize posture, then use BDPC for the intensity-modulated radiotherapy. Target area conformability index（CI）, homogeneity index （HI）, dose of endangerment organ （OAR） and beam connecting dose distribution are evaluated. The use of base-dose- compensation intensity-modulated plan combined with whole-body positioning technology improves the target area conformability and target uniformity, simplifies the design of craniospinal radiotherapy, improves the placement accuracy and ensure good placement repeatability. We measure beam connecting dose distribution. Cold and hot spots do not appear, and calculated values are basically identical. The application of whole-body positioning technique combined with BDPC optimization method in the treatment of the craniospinal radiotherapy meets the clinical requirements of dosimetry. Moreover, it is simple and can improve the treatment planning efficiency.