肌腱干细胞在骨肌腱接点纤维软骨带重建中的作用机制研究进展

Mechanism research progress of tendon-derived stem cells in reconstruction of fibrocartilage zone at bone-tendon junction

目的对肌腱干细胞(tendon-derived stem cells,TDSCs)在骨肌腱接点(bone-tendon junction,BTJ)纤维软骨带重建中的作用机制进行综述。方法广泛查阅国内外有关TDSCs促进BTJ纤维软骨带重建的研究文献,并总结分析。结果 TDSCs具有向骨细胞、纤维软骨细胞及肌腱细胞分化的能力,因此具备形成纤维软骨带的潜能;决定TDSCs成骨、成软骨分化的因素有力学刺激、生物活性因子、细胞外基质及炎性因子等。结论TDSCs因其来源的特殊性,具有成为重建BTJ纤维软骨带种子细胞的潜能,通过外界刺激可诱导TDSCs形成类似于纤维软骨带结构。

Objective To summarize the mechanism research progress of tendon-derived stem cells （TDSCs） in the reconstruction of flbrocartilage zone at bone-tendon junction （BTJ）. Methods The domestic and abroad related literature about TDSCs in the reconstruction of flbrocartilage zone at BTJ was summarized and analyzed. Results TDSCs can be induced to osteocytes, fibrochondrocytes, and tenocytes in vitro. Therefore, TDSCs have potential to reconstruct flbrocartilage zone at BTJ. Factors, such as mechanical stimulation, bioactive factor, extracelluar matrix, inflammatory factors, and so on, may influence osteogenic or chondrogenic differentiation of TDSCs. Conclusion Because of the specificity of origin and location ofTDSCs, TDSCs have the potential to be the seed cells for BTJ flbrocartilage zone repair. By applying external stimuli, TDSCs can be induced to form structures which are similar to flbrocartilage zone.