不同透析方式对糖尿病肾病尿毒症患者皮肤瘙痒的疗效比较

Effect Comparison of Different Dialysis Methods on Diabetic Nephropathy Uremia Patients with Cutaneous Pruritus

目的:探讨不同透析方式对糖尿病肾病尿毒症患者皮肤瘙痒程度的影响。方法:选取2016年2-12月收治的糖尿病肾病尿毒症患者41例,采取高通量血液透析,作为观察组;选取2015年2-12月收治的糖尿病肾病尿毒症患者41例,采取常规血液透析,作为对照组。比较治疗前、治疗3个月后两组患者瘙痒程度以及生化指标变化情况。结果:两组治疗前皮肤瘙痒程度比较,差异无统计学意义(P>0.05);治疗3个月后,观察组皮肤瘙痒程度较治疗前显著改善(P<0.05);对照组治疗前后皮肤瘙痒程度无显著改善(P>0.05)。观察组治疗3个月后,血Cr、BUN、Ca、P、PTH、β2-M指标水平较治疗前显著改善(P<0.05);对照组治疗前、后血Cr、BUN、Ca、P、PTH、β2-M指标水平无显著改善(P>0.05)。结论:高通量血液透析治疗糖尿病肾病尿毒症患者皮肤瘙痒临床疗效好,值得临床推广。

Objective：To investigate the effect of different dialysis methods on diabetic nephropathy uremia patients with cutaneous pruritus.Methods：From February 2016 to December 2016,41 patients with diabetic nephropathy uremia treated with high-flux hemodialysis were selected as the observation group,from February 2015 to December 2015,41 patients with diabetic nephropathy uremia treated with conventional hemodialysis were selected as the control group,The changes of pruritus and biochemical parameters in two groups were compared before and after treatment for 3months.Results：There was no significant difference in the degree of pruritus in the two groups before treatment（P〉0.05）;after 3months of treatment,the degree of pruritus was significantly improved in the observation group（P〈0.05）;there was no significant difference in control group between before and after treatment（P〉0.05）.After 3months of treatment,the levels of Cr,BUN,Ca,P,PTH,andβ2-M were significantly improved in the observation group（P〈0.05）.there was no significant difference in control group between before and after treatment（P〉0.05）.Conclusion：High-flux hemodialysis has a good effect in treating diabetic nephropathy uremia patients with cutaneous pruritus,it is worthy of clinical promotion.