磁共振成像在抑郁症疗效预测中的作用

The role of magnetic resonance imaging in predicting the efficacy of depression

抑郁症是一种常见的心理精神障碍，发病率高，治疗缓解率低。目前对于抑郁症疗效预测的研究局限于临床特征和神经影像学。综述近年来磁共振成像对抑郁症疗效预测的研究结果，旨在寻找预测抑郁症疗效的客观影像学标记物。目前疗效预测的研究主要集中于情绪调节环路，较少涉及奖赏神经环路，前额叶、扣带回、杏仁核及海马在疗效预测中具有重要作用。磁共振成像对抑郁症疗效预测的研究是一个可行的研究领域。需要更多的研究发现奖赏神经环路对抗抑郁药物疗效预测的作用，采用多模态的磁共振成像方法来检测相关抑郁症神经环路以及能够预测疗效的脑的结构和功能。

Depression is a common mental disorder with high incidence rate and low remission rate. The prediction of therapeutic effect in depression is limited to clinical features and neuroimaging. Reviewed the results of magnetic resonance imaging for predicting the treatment response in depression and explored the objective image markers for predicting the therapeutic effect in depression. It showed that the studies mainly focused on emotion regulation neural circuitry and few on reward neural circuitry. Prefrontal cortex, cingulate cortex, amygdala and hippocampus play important roles on predicting therapeutic effect. The study of magnet- ic resonance imaging for predicting therapeutic effect in depression is a feasible research field. More resear- ches of finding the role of reward neural circuits in predicting the effect of antidepressants are needed. The brain structure and function of the neural circuits involved in depression and predicting the effect of anti-de- pression need to be studied by muhimodal MRI method.