主观记忆减退老年人脑结构与功能的可塑性

Brain plasticity of structural and functional in elderly with subjective memory complaints

主观记忆减退（subjective memory complaints，SMC）期是阿尔兹海默病（Alzheimer’s disease，AD）发病进程的最初始阶段。影像学证据显示，虽然主观记忆减退老年人在行为测验上的成绩还没表现出明显下降，但其大脑可能已经发生了生理病理性改变。在主观记忆减退期开展有针对性干预是预防和延缓AD发生的有效切入点，但针对主观记忆减退老年人脑结构与功能的可塑性研究尚处于起步阶段。将主观记忆减退的脑机制研究和脑可塑性研究相结合，在深入阐明其生理病理机制的基础上采取有针对性的干预措施，对于理解脑老化和预防AD具有重要意义。

Subjective memory complaints （SMC） is increasingly recognized as the earliest prodro- mal stage of Alzheimer＇ s disease. Individuals with SMC whose memory without measurable cognitive deficits, however,demonstrated some neurodegenerative brain changes. It would be more appropriate to prevent or postpone the AD process by interventing in this earlier stage of SMC, while relatively little is known about the brain plasticity in elderly with SMC. Therefore ,further research is necessary in understanding the brain plas- ticity in SMC on the basis of further elucidating the pathophysiological mechanisms in this group of individuals.