探讨血清总胆汁酸在新生儿黄疸时浓度的变化及临床意义

To Investigate the Change of Serum Total Bile Acid(TBA) Concentration in Neonatal Jaundice and its Clinical Significance

目的对新生儿黄疸时血清总胆汁酸浓度变化情况和临床意义,为临床治疗提供参考。方法根据我院2014年11月—2015年12月接收的49例新生黄疸儿进行分析研究,分成生理组29例,病理组20例,选取49例健康儿作为对照组,对3组患儿的血清总胆汁酸(TBA)、间接胆红素(IBIL)、总胆红素(TBIL)水平对比分析研究。结果对照组TBA平均(9.17±0.69)μmol/L、IBIL平均(11.98±2.58)μmol/L、TBIL平均(19.04±3.64)μmol/L,生理组分别为(9.34±0.86)μmol/L、(127.68±20.58)μmol/L、(160.98±27.68)μmol/L,病理组分别为(31.67±9.23)μmol/L、(201.34±24.65)μmol/L、(251.67±29.99)μmol/L,生理组和病理组的以上指标比对照组高,差异有统计学意义(P<0.05)。结论新生儿黄疸使用胆红素检测结合总胆汁酸检测对患儿的病情能进行精准的诊断,为预后提供帮助,让患儿更快恢复健康。

Objective To investigate the change of serum total bile acid concentration in neonatal jaundice and its clinical significance, so as to provide reference for clinical treatment. Methods According to the analysis of our hospital in November 2014 to December 2015 received 49 cases of neonatal jaundice, divided into normal group of 29 cases, 20 cases of pathological group, 49 healthy children were selected as control group, serum total bile acid in three groups（TBA）, indirect bilirubin（IBIL）, total bilirubin（TBIL） level analysis contrast. Results The control group average TBA（9.17±0.69） μmol/L, IBIL average（11.98±2.58） μmol/L, TBIL average（19.04±3.64） μmol/L, physiological group respectively（9.34±0.86） μmol/L,（127.68±20.58） μmol/L,（160.98±27.68） μmol/L, pathology group respectively（31.67±9.23） μmol/L,（201.34±24.65） μmol/L,（251.67±29.99）μmol/L, indexes in the physiological and pathological groups were higher than those in the control group, and the difference was statistically significant（P〈0.05）. Conclusion Neonatal jaundice using bilirubin testing, combined with total bile acid testing, accurate diagnosis of the condition of children, to provide help for prognosis, so that children faster recovery health.