胺碘酮联合美托洛尔治疗老年冠心病并发心律失常的临床疗效

Clinical Efficacy of Amiodarone Combined With Metoprolol in the Treatment of Senile Coronary Heart Disease Complicated With Arrhythmia

目的研究治疗老年冠心病并发心律失常患者时使用胺碘酮联合美托洛尔的治疗效果。方法收集老年冠心病并发心律失常患者共124例,按照完全随机化分组原则将其分为对照组(62例)和观察组(62例),对照组的治疗药物为胺碘酮,观察组联合美托洛尔,将两组QT间期离散度、心率改善情况以及不良反应发生率进行观察和对比。结果相较于对照组,观察组的QT间期离散度、心率改善情况均更优,P<0.05。在不良反应发生率方面,两组差异无统计学意义,P>0.05。结论在老年冠心病并发心律失常患者的治疗过程中,胺碘酮联合美托洛尔能够显著改善患者心功能,用药安全性高。

Objective To study the effect of amiodarone combined with metoprolol in the treatment of elderly patients with coronary heart disease complicated with arrhythmia. Methods A total of 124 elderly patients with coronary heart disease complicated with arrhythmia were collected, according to the principle of complete randomization, the patients were divided into control group（62 cases） and observation group（62 cases）, control group was treated with amiodarone, and the observation group was treated with metoprolol, QT interval dispersion, heart rate improvement and incidence of adverse reactions were observed and compared between the two groups. Results Compared with the control group, the QT interval dispersion and heart rate improvement in the observation group were better, P〈0.05. In the incidence of adverse reactions, the difference between the two groups was not statistically significant, P〉0.05. Conclusion In the treatment of elderly coronary heart disease complicated with arrhythmia, amiodarone combined with metoprolol can significantly improve the heart function of patients with high safety.