产后抑郁的预测因素及神经生理机制

Predictive factors and the neurophysiological mechanism of postpartum depression

产后抑郁是产后时期出现的抑郁症状,对女性及其后代甚至家人都会造成严重的负面影响。产后抑郁稳定的预测因素是遗传基因、依恋风格、童年负性生活经历和激素水平的变化;涉及的脑区和神经网络集中在前额叶皮层、扣带回、杏仁核和海马等脑区及相应神经网络。未来应在探索综合的预测模型、男性伴侣的对照试验和基于大脑可塑性特征的干预模式等方面展开深入研究。

Postpartum depression （PPD） refers to the depression symptoms that appear in the postpartum period which has negative impact on the health and well-being of a large number of new mothers, their offspring, and the rest of their family＇s members. In the present review, key predictive factors of PPD are discussed, including genetic gene, attachment styles, negative experience of the childhood and hormone level changes. The neural network and brain regions related to PPD are resided largely in the prefrontal cortex, the cingulate cortex, the amygdale, the hippocampus and the other parts in the brain and their corresponding neural network. Future research in this field should focus on exploring an integrated predictive model, an etiology model of PPD, controlled trials of male partners and an intervention model based on characteristics of brain plasticity.