IBD血清学标志物的临床应用前景

Clinical application prospects of serum markers for inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)是一种病因不明的慢性非特异性肠道炎症性疾病,包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(Crohn's disease,CD).目前IBD的诊断及临床过程主要依据其临床表现、常规检验、影像学特征、内镜所见及组织病理综合判断,但远未满足临床实践.因此,寻找一种简单、准确的诊断方法成为目前亟待解决的问题.迄今,IBD相关血清学标志物的应用对IBD的诊断与鉴别诊断、疾病严重程度界定、疗效判断和预后评估均凸显出其临床优势.本文就近年来IBD血清学标志物的研究及其临床应用前景作一述评.

Inflammatory bowel disease （IBD） is a chronic non-specific intestinal inflammatory disease with unknown etiology, including ulcerative colitis （UC） and Crohn＇s disease （CD）. Current clinical diagnosis of IBD mainly relies on clinical manifestations, routine blood tests, imaging, endoscopic and histopathological evaluations. However, all these approaches are not satisfying in clinical practice. There is currently an urgent need to find a simple and accurate diagnostic method. IBD-related serological markers have many advantages in the diagnosis and differential diagnosis, assessment of disease severity, and judgment of curative effect and prognosis in IBD. This paper will discuss the potential clinical application prospects of serum markers for IBD.