阿托伐他汀对急性心肌梗死患者血清C-反应蛋白和白细胞介素-1的影响及临床意义

Effects of Atorvastatin on Interleukin-1 and C-reactive Protein Levels of Patients with Acute Myocardial Infarction

目的观察不同剂量阿托伐他汀对急性心肌梗死(AMI)患者血清C-反应蛋白(CRP)和白细胞介素-1(IL-1)的影响,为明确其量效关系提供参考。方法 80例AMI患者随机分为2组:观察组和对照组,每组40例。对照组口服阿托伐他汀钙片20 mg/晚,观察组口服阿托伐他汀钙片40 mg/晚,2组均服药4周;同时设定40例健康体检者为空白对照组。分别测定各组治疗前后血清CRP和IL-1水平,并进行比较与分析。结果治疗前观察组和对照组CRP和IL-1水平均明显高于空白对照组(均P<0.01);治疗后2组患者CRP和IL-1水平明显低于治疗前水平(均P<0.01),观察组CRP和IL-1水平明显低于对照组(P<0.01)。结论在AMI患者发病早期使用阿托伐他汀,能够更有效地抑制炎症反应,且有量效关系,可能有助于脂质斑块稳定和预后改善。

Objective To observe the effect of different dose of atorvastatin on interleukin-1（IL-1） and C-reactive protein（CRP） levels of patients with acute myocardial infarction（AMI） so as to provide reference for the determination of the dose-effect relationship.Methods 80 patients with AMI were randomly divided into 2 groups：observation group and control group,40 in each;oral administration of atorvastatin 20 mg per day was made to patients in control group while that of atorvastatin 40 mg per day was made to patients in observation gorup;the course lasted for 4 weeks for both groups;40norm were selected to be blank control group;detections of CRP and IL-1 levels before and after treatment were performed in each group and the results were compared and analyzed.Results Before treatment,the CRP and IL-1 levels of the patients in observation group and control group were much higher than those in blank control group（P〈0.01）;after treatment,the levels of CRP and EL-1 of the patients in both group were obviously lower than those before treatment（P〈0.01） and the levels in observation group were much lower than those in control group（P〈0.01）.Conclusions The administration of atorvastatin to patients with early AMI can effectively control the inflammation and the dose-effect relationship may help the stability of lipid plaques and the improvement of prognosis.