摘要
目的建立复方蛤青胶囊的质量标准。方法采用薄层色谱(TLC)法定性鉴别制剂中的紫菀、前胡和五味子;采用高效液相色谱(HPLC)法测定制剂中黄芪甲苷和苦杏仁苷的含量。结果建立的TLC法科学,专属性强;黄芪甲苷进样量在0.946~9.46μg范围内与峰面积线性关系良好,r=0.999 5,平均回收率为101.12%,RSD为4.17%(n=7);苦杏仁苷进样量在0.370~5.813μg范围内与峰面积线性关系良好,r=0.999 6,平均回收率为96.83%,RSD为3.08%(n=8)。结论建立的方法科学、简便、专属性较强,可有效控制复方蛤青胶囊的质量。
Objective To establish the quality standard for Fufang Haqing Capsule. Methods TLC method was used to identify Aster Tataricus,Radix Astragali,Peucedanum Praeruptorum,Schisandrae Chinensis Fructus. HPLC was used to determine the content of astraga-loside and amygdalin. Results The methods of TLC were scientific and strong specificity. The linear range of astragaloside was 0. 946-9. 46 μg（r=0. 9995）. The average recovery was 101. 12% with the RSD of 4. 17% （ n=7 ） . The linear range of amygdalin was 0. 370-5. 813 μg（r=0. 9996）. The average recovery was 96. 83% with the RSD of 3. 08%（ n=8 ） . Conclusion The method is sci-entific,simple and strong specificity,which can be used for quality control of Fufang Haqing Capsule.
作者
吴芳
杨燕子
樊宝娟
罗定强
戴涌
Wu Fang Yang Yanzi Fan Baojuan Luo Dingqiang Dai Yong(Shaanxi Institute for Food and Drug Control, Xi＇ an, Shaanxi, China 710061)
出处
《中国药业》
CAS
2017年第12期30-34,共5页
China Pharmaceuticals
关键词
复方蛤青胶囊
紫菀
前胡
五味子
黄芪甲苷
苦杏仁苷
质量标准
Fufang Haqing Capsule
Aster Tataricus
Peucedanum Praeruptorum
Schisandrae Chinensis Fructus
astragaloside
amygdalin
quality standard
