血清脂质与脂质过氧化关系的临床研究

CLINICAL STUDIES ON THE RELATIONSHIP BETWEEN SERUM LIPIDS AND LIPID PEROXIDATION

观察90例不同血脂水平的职工,发现高血脂者血清丙二醛(MDA)水平明显高于正常血脂者(P<0.001),而红细胞超氧化物歧化酶(SOD)活性两者间无明显差异(P>0.05)。多元回归分析表明,MDA仅与血清非高密度脂蛋白胆固醇呈正相关,而SOD仅与高密度脂蛋白胆固醇呈正相关。高血脂者经调节血脂治疗后,MDA明显下降,而SOD无明显变化,提示高脂血症与脂质过氧化间有一定关系。

This paper presented the relationship between serum lipid fractions, lipid peroxides (LPO) and antioxidants in man. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), malondialdehyde (MDA) and erythrocyte superoxide dismutase (SOD) activity were measured in 90 subjects with different serum lipid levels. It was found that the concentration of serum MDA in hyperlipidemia (2.87±0.837nmol/ml) was significantly higher than that in normolipidemia (2.30±0.526nmol/ml, P<0.001); there was no significant difference in SOD activity between hyperlipidemia and normolipidemia. Multiple regression analysis showed that MDA had close positive correlation with non-high density lipoprotein-cholesterol (NHDL-C=TC minus HDL-C) (P=0.001), and SOD had positive correlation with HDL-C (P<0.01). 53 subjects with hyperlipidemia were divided into two groups: 37 in treatment group received gemfibrozil and 16 in control. The results showed significant decrease in serum TC, TG, NHDL-C and TC/HDL-C, and increase in HDL-C, meanwhile serum MDA decreased significantly from 2.85±0.78 to 2.52±0.69nmol/ml (P<0.05), but SOD activity had no significant change after the treatment. All the parameters showed no significant change in the control group. This suggests that hyperlipidemia is associated with lipid peroxidation which might be one of the causes for hyperlipidemia as a risk factor of atherosclerosis.